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Use of body surface potential maps for model-based assessment of local pathological changes in the heart

Wybrane pełne teksty z tego czasopisma
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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
High resolution body surface potential maps and an equivalent current dipole model of the cardiac generator were used to assess the heart state in two abnormal conditions: WPW syndrome with single accessory pathway and local ventricular ischemia. Results of a simulation study and experimental verification of the method for both cardiologic abnormalities are presented. Single accessory pathway in WPW syndrome was simulated as initial ventricular activation at the atrio-ventricular ring. Using a current dipole model of the cardiac generator, the locus of arrhythmogenic tissue was assessed with a mean error of 11 mm. Experimental localization of the accessory pathway in a WPW patient was in good agreement with the invasively obtained site. Local repolarization changes were simulated as shortening of the myocytes action potentials in three regions typical for stenosis of main coronary arteries. Using surface QRST integral maps and dipolar source model, small subendocardial and subepicardial lesions of myocardium were inversely located with a mean error of 9 mm and larger transmural lesions with a considerable mean error of 17 mm. Extent and prevalence of subepicardial or subendocardial type of the lesion were reflected in the dipole moment and orientation. In experimental verification of the method, in 7 of 8 patients that underwent PCI of a single vessel, estimated equivalent current dipole position matched well the treated vessel. The results suggest that diagnostic interpretation of body surface potential maps based on dipolar source model could be a useful tool to assess local pathological changes in the heart.
Rocznik
Strony
207--215
Opis fizyczny
Bibliogr. 11 poz., 12 rys., 3 tab.
Twórcy
autor
autor
autor
autor
  • Institute of Measurement Science, Slovak Academy of Sciences, Dubravska cesta 9, 84104 Bratislava, Slovakia., tysler@savba.sk
Bibliografia
  • [1] V. Szathmáry and I. Ruttkay-Nedecký, “Effects of different sources of ventricular repolarization heterogeneity on the resultant cardiac vectors. A model study”, Health Data in the Information Society. Proceedings of MIE2002, 88–92 (2002).
  • [2] V. Szathmáry and R. Osvald, “An interactive computer model of propagated activation with analytically defined geometry of ventricles”, Comput. Biomed. Res. 27, 27–38 (1998).
  • [3] R. Hren, G. Stroink, and B.M. Horacek, “Accuracy of single-dipole inverse solution when localising ventricular preexcitation sites: simulation study”, Med. Biol. Eng. Comp. 36, 323–328 (1998).
  • [4] G.X. Yan, W. Shimizu, and Ch. Antzelevich, “Characteristics and distribution of M cells in anterially perfused canine left ventricular wedge preparations”, Circulation 98, 1921–1927 (1998).
  • [5] G.R. Li, J. Feng, L. Yue, and M. Carrier, “Transmural heterogeneity of action potentials and Ito1 in myocytes isolated from the human right ventricle”, Am. J. Physiol. 275, H369–H377 (1998).
  • [6] M. Tyšler, M. Turzová, M. Tiˇnová, and J. Švehlíková, “Accuracy evaluation of non-invasive localization of accessory pathways”, Biomedizinische Technik 42 (1), 281–284 (1997).
  • [7] A.V. Shahidi, P. Savard, and R. Nadeau, “Forward and inverse problems of electrocardiography: modeling and recovery of epicardial potentials in humans”, IEEE Trans. Biomed. Eng. 41, 249–256 (1994).
  • [8] M. Tiˇnová, M. Tyšler, and M. Turzová “Inverse localization of preexcitation sites using a jumping dipole”, Journal of Electrocardiology 30, 348 (1997).
  • [9] M. Tysler, M. Turzova, and S. Filipova, “Assessment of local repolarization changes using model based BSPM interpretation”, Advances in Electrocardiology 2004, 158–162 (2005).
  • [10] R.L. Lux, C.R. Smith, R.F.Wyatt, and J.A. Abildskov, “Limited lead selection for estimation of body surface potential maps in electrocardiography”, IEEE Trans. Biomed. Eng. 25, 270–276 (1978).
  • [11] G.J.M. Huiskamp, T. Oostendorp, N.H.J. Pijls, and A. van Oosterom, “Invasive confirmation of the human ventricular activation sequence as computed from body surface potentials” Computers in Cardiology ’92, (1992).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BPG5-0006-0002
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