Elastomeric nanocomposites for myocardial tissune engineering

• Autorzy: Piegat A. , EL Fray M. , Boccaccini A. R.
• Języki publikacji: EN

Abstrakty

EN

In this work we present the results of surface topography and cell adhesion investigations of new elastomeric materials composed of poly(ethylcnc tercphthalatc) (PET) hard segments and dimer fatty acid, i.e. dilinoleic acid (DLA) soft segments. 0.2 wt % TiOn nanoparticles were introduced into polymer matrix to form polymer-ceramic nanocomposite. Addition ofTi02 nanoparticles altered surface roughness and enhanced embryonic stem cells cardiomyocytes (ESC-CM) derived from mouse embryonic stem cells adhesion and spreading. The results indicate that PET/DLA and especially PET/DLA-TiOj are promising candidates for the manufacture of engineered patches with ESC-CM.

Słowa kluczowe

EN

thermoplastic elastomer; nanocomposite; tissure engineering

PL

elastometr termoplastyczny; nanokompozyty; inżynieria tkankowa

• Wydawca: Centrum Materiałów Polimerowych i Węglowych PAN
• Czasopismo: Polish Journal of Applied Chemistry
• Rocznik: 2009
• Tom: Vol. 53, nr 2
• Strony: 169--174
• Opis fizyczny: Bibliogr. 7 poz., rys.

Twórcy

autor

Piegat A.

autor

EL Fray M.

autor

Boccaccini A. R.

• Szczecin University of Technology, Polymer Institute, Division of Biomaterials and Microbiological Technologies, Pułaskiego 10, 70-322 Szczecin, Poland,

Bibliografia

• [1] Chu, P.K., Liu, X., Biomaterials Fabrication and Processing, Handbook, CRC Press, 2008.
• [2] Zammaretti, P., Jaconi, M., Curr. Opin. Biotechno]., 2004, 15, 430.
• [3] Ozawa, T., Mickle, D.A.G., Wicsel, R.D., Koyama, N., Ozawa, S., Li, R.-K., Circulation, 2002,106, 176
• [4] Zund, G., Breuer, C.K., Shinoka, T., Ma, P.X., Langer, R., Mayer, J.E., Vacanti, J.P., Eur. J. Cardiothorac. Surg., 1997,//, 493.
• [5] McDevitt, T.C., Woodhouse, K.A., Hauschka, S.D., Murry, C.E., Stayton, P.S., J. Biomed. Mater. Res., 2003,66/4,586.
• [6] El Fray, M., Boccaccini, A.R., Mater. Lett., 2005, 59, 2300.
• [7] Ettlinger, M., Fine Particles, Technical Bulletin Pigments, No. 80, Degussa AG, Inorganic Chemical Products Division: Duesseldorf., p. 5.