Functional poly (ester-anhydride) microspheres

• Autorzy: Jaszcz K. , Łukaszczyk J.
• Języki publikacji: EN

Abstrakty

EN

Functional microspheres were prepared from poIy(ester-anhydride)s with allyl pendant groups, using a solvent removal technique. The poly(ester-anhydride)s were obtained by polycondensation of sebacic acid (SBA) and oligo(3-allyloxy-l,2-propylene succinate) terminated with carboxyl groups (OSAGE). The SBA and OSAGE content influenced the characteristics of poly(ester-anhydride)s and microspheres. The poly(ester-anhydride)s differed with their solubility and thermal properties as well as their degradation rate and mode. Stable microspheres with size in the range of 15-60 nm were obtained from poly(ester-anhydride)s containing more than 60% SBA. The microspheres obtained from po!y(ester-anhydride)s containing 60% SBA had tendency to aggregation. Microspheres were not obtained when content of SBA in poly(ester-anhydride)s was lower than 60%. All particles were spherical, however those prepared from polymers containing 90 or 80% SBA possessed smoother surfaces when compared to those prepared from poly(ester-anhydride)s containing 70 or 60% SBA. Ability of poIy(ester-anhydride)s to be formulated as microspheres would enable their eventual use in drug delivery systems.

Słowa kluczowe

EN

functional poly(ester-anhydride); poly(ester-anhydride); functional microspheres; allyl groups

PL

funkcjonalne poli(ester-bezwodnik); poli(estro-bezwodnik); funkcjonalne mikrosfery; grupy allilowe

• Wydawca: Centrum Materiałów Polimerowych i Węglowych PAN
• Czasopismo: Polish Journal of Applied Chemistry
• Rocznik: 2009
• Tom: Vol. 53, nr 1
• Strony: 1--7
• Opis fizyczny: Bibliogr. 10 poz., rys.

Twórcy

autor

Jaszcz K.

autor

Łukaszczyk J.

• Departament of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland,

Bibliografia

• [1] Domb, A.J., Amselem, S., Shah, J., Maniar, M., Adv. Polym. Sci., 1993, 107, 93.
• [2] Gopferich, A., Tessmar, J,,Adv. Drug Deliv. Rev., 2002, 54, 911.
• [3] Kumar, N., Langer, R.S., Domb, A.J., Adv. Drug Deliv. Rev., 2002, 54, 889.
• [4] Edlund, U., Albertsson, A.-C,,Adv. Drug Deliv. Rev., 2003, 55, 585.
• [5] Erdmann, L., Uhrich, K.E., Biomaterials, 2000, 21, 1941.
• [6] Pfeifer, B.A., Burdick, J.A., Langer, R., Biomaterials 2005, 26, 117.
• [7] Miao, H., Fan, Y., Liu, Y., Hao, J., Deng, X., Eur. Polym. J., 2007, 43, 1055.
• [8] Jaszcz, K., Macromol. Symp., 2007, 254, 109.
• [9] Jaszcz, K., Łukaszczyk, J., Smiga-Matuszowicz, M., React. Fund. Polym., 2008, 68 351.
• [10]Kowalczyk, D., Słomkowski, S., Polimery 1992, 37, 442.