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Finite element modelling of the cervical spinal cord injury - clinical assessment

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Języki publikacji
EN
Abstrakty
EN
The aim of the study was to evaluate the efficiency of Finite Element Method (FEM) modelling of the clinical cases of traumatic cervical spinal cord injury (SCI). The study population consisted of 28 patients suffering from traumatic cervical spine injury with (study group) and without (control) neurological deficits. A numerical simulation of the trauma event was performed, based on validated 3D FEM model. All the results obtained underwent statistical analysis. Statistically significant differences between both groups were found in severity of bony and neural structure damage as well as in stress and strain ratios. The highest values of tensile stress and deformation were noted in the sagittal (Y) axis. The maximum stress and strain were found in anterior spinothalamic, lateral spinothalamic and dorsal columns. It was also found that stress and strain in each segment and axis of the spinal cord model were positively correlated with the severity of the cervical spine injury (R-Spearman 0.39 to 0.64) and neurological symptoms of SCI (R-Spearman: 0.43 to 0.82). It is possible to create a clinical numerical model of the SCI with the use of FEM. The correlations between the mechanical force and neurological deficits show tendencies which require further studies based on an improved model and a greater number of patients.
Rocznik
Strony
23--29
Opis fizyczny
Bibliogr. 22 poz., rys., tab.
Twórcy
autor
autor
Bibliografia
  • [1] SHARMA H.S., Pathophysiology of blood-spinal cord barrier in traumatic injury and repair, Curr. Pharm. Des., 2005, 11(11), 1353–1389.
  • [2] MAIKOS J.T., SHREIBER D.I., Immediate damage to the bloodspinal cord barrier due to mechanical trauma, J. Neurotrauma, 2007, 24(3), 492–507.
  • [3] PANJABI M., WHITE A. 3rd, Biomechanics of nonacute cervical spinal cord trauma, Spine (Phila Pa 1976), 1988, 13(7), 838–842.
  • [4] GREAVES C.Y., GADALA M.S., OXLAND T.R., A threedimensional finite element model of the cervical spine with spinal cord: an investigation of three injury mechanisms, Ann. Biomed. Eng., 2008, 36(3), 396–405.
  • [5] LI X.F., DAI L.Y., Three-dimensional finite element model of the cervical spinal cord: preliminary results of injury mechanism analysis, Spine (Phila Pa 1976), 2009, 34(11), 1140–1147.
  • [6] WILCOX R.K., ALLEN D.J., HALL R.M., LIMB D., BARTON D.C., DICKSON R.A., A dynamic investigation of the burst fracture process using a combined experimental and finite element approach, Eur. Spine J., 2004, 13(6), 481–488.
  • [7] ICHIHARA K., TAGUCHI T., SAKURAMOTO I., KAWANO S., KAWAI S., Mechanism of the spinal cord injury and the cervical spondylotic myelopathy: new approach based on the mechanical features of the spinal cord white and gray matter, J. Neurosurg., 2003, 99(3 Suppl), 278–285.
  • [8] VAN MIDDENDORP J.J., POUW M.H., HAYES K.C., WILLIAMS R., CHHABRA H.S., PUTZ C., VETH R.P., GEURTS A.C., AITO S., KRIZ J., MCKINLEY W., VAN ASBECK F.W., CURT A., FEHLINGS M.G., VAN DE MEENT H., HOSMAN A.J., Diagnostic criteria of traumatic central cord syndrome, Part 2: a questionnaire survey among spine specialists, Spinal Cord., 2010, 48(9), 657–663.
  • [9] MOORE T.A., VACCARO A.R., ANDERSON P.A., Classification of lower cervical spine injuries, Spine (Phila Pa 1976), 2006, 31(11 Suppl), S37-43; discussion S61.
  • [10] WARING W.P. 3rd., BIERING-SORENSEN F., BURNS S., DONOVAN W., GRAVES D., JHA A., JONES L., KIRSHBLUM S., MARINO R., MULCAHEY M.J., REEVES R., SCELZA W.M., SCHMIDT-READ M., STEIN A., 2009 review and revisions of the international standards for the neurological classification of spinal cord injury, J. Spinal Cord. Med., 2010, 33(4), 346–352.
  • [11] CZYŻ M., ŚCIGAŁA K., JARMUNDOWICZ W., BĘDZIŃSKI R., Numerical model of the human cervical spinal cord – the development and validation, Acta Bioeng. Biomech., 2011, 13(4), 51–58.
  • [12] HALL R.M., OAKLAND R.J., WILCOX R.K., BARTON D.C., Spinal cord-fragment interactions following burst fracture: an in vitro model, J. Neurosurg. Spine, 2006, 5(3), 243–250.
  • [13] GARCIA-ALIAS G., LOPEZ-VALES R., FORES J., NAVARRO X., VERDU E., Acute transplantation of olfactory ensheathing cells or Schwann cells promotes recovery after spinal cord injury in the rat, J. Neurosci. Res., 2004, 75(5), 632–641.
  • [14] RESNICK D.K., CECHVALA C.F., YAN Y., WITWER B.P., SUN D., ZHANG S., Adult olfactory ensheathing cell transplantation for acute spinal cord injury, J. Neurotrauma, 2003, 20(3), 279–285.
  • [15] MAIKOS J.T., QIAN Z., METAXAS D., SHREIBER D.I., Finite element analysis of spinal cord injury in the rat, J. Neurotrauma, 2008, 25(7), 795–816.
  • [16] MAZGAJCZYK E., ŚCIGAŁA K., CZYŻ M., JARMUNDOWICZ W., BĘDZIŃSKI R., Mechanical properties of cervical dura mater, Acta Bioeng. Biomech., 2012, 14(1), 51–58.
  • [17] WILCOX R.K., BOERGER T.O., ALLEN D.J., BARTON D.C., LIMB D., DICKSON R.A., HALL R.M., A dynamic study of thoracolumbar burst fractures, J. Bone Joint Surg. Am., 2003, 85-A(11), 2184–2189.
  • [18] TUBBS R.S., SALTER G., GRABB P.A., OAKES W.J., The denticulate ligament: anatomy and functional significance, J. Neurosurg., 2001, 94(2 Suppl), 271–275.
  • [19] STOLTMANN H.F., BLACKWOOD W., An anatomical study of the role of the detate ligaments in the cervical spinal canal, J. Neurosurg., 1966, 24(1), 43–46.
  • [20] LIM P.A., TOW A.M., Recovery and regeneration after spinal cord injury: a review and summary of recent literature, Ann. Acad. Med. Singapore, 2007, 36(1), 49–57.
  • [21] HEIL M., An efficient solver for the fully coupled solution of large-displacement fluid-structure interaction problems, Computer Methods in Applied Mechanics and Engineering, 2004, 193(1–2), 1–23.
  • [22] PERSSON C., SUMMERS J., HALL R.M., The importance of fluid-structure interaction in spinal trauma models, J. Neurotrauma, 2011, 28(1), 113–125.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BPBD-0003-0030
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