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Spray drying as a method of producing silk sericin powders

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Aqueous sericin solutions were used as raw material for the production of dry powders using a lab-scale spray dryer. A linear regression analysis of agglomeration was employed, in addition to experimental designs at two levels with three factors for the analysis of three responses: moisture content, particle type and agglomeration degree. The process factors were the drying air temperature (120 degree C and 160 degree C), the feed rate (1.25 × 10 to -7 and 2.5 × 10 to -7 m3/s), and the concentration of sericin solutions of 10% and 30% (w/w) fed to the spray dryer. The three responses were analyzed statistically to determine the effective parameters and it was concluded that moisture content depended on three factors--drying air temperature being the dominant parameter. Particle size and shape depended mainly on feed rate and agglomeration depended on the moisture content of the product.
Rocznik
Strony
16--28
Opis fizyczny
Bibliogr. 22 poz., rys., tabl.
Twórcy
autor
autor
autor
Bibliografia
  • [1] G.H. Altman, F.Diaz, C. Jakuba, T. Calabro, R.L. Horan, J. Chen, H. Lu, J. Richmond, D.L. Kaplan, Silk-based biomaterial, Biomaterials 24 (2003) 401-416.
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  • [3] M. Irngartinger, V. Camuglia, M. Damm, J. Goede, H.W. Frijlink, Pulmonary delivery of therapeutic peptides via dry powder inhalation: effects of micronisation and manufacturing, European Journal of Pharmaceutics and Biopharmaceutics 58 (2004) 7-14.
  • [4] H.J. Jin, J. Chen, V. Karageorgiou, G.H. Altman, D.L. Kaplan, Human bone marrow stromal cell responses on electrospun silk fibroin mats, Biomaterials 25 (2004) 1039-1047.
  • [5] K.A. Johnson, Preparation of peptide and protein powders for inhalation, Advanced Drug Delivey Reviews 26 (1997) 3-15.
  • [6] N.M. Kassem, K.K.L Ho, D. Ganderton, The effect of airflow and carrier size on the characteristics of an inspirable cloud, Journal of Pharmacy and Pharmacology 41(1989) 13.
  • [7] N. Kato, S. Sato, A. Yamanaka, H. Yamada, N. Fuwa, M. Nomura, Silk protein, sericin, inhibits lipid peroxidation and tyrosinase activity, Bioscience Biotechnology and Biochemistry 62 (1998) 145-147.
  • [8] A. Kongdee, T. Bechtold, L. Teufel, Modification of cellulose fiber with silk sericin, Journal of Applied Polymer Science 96 (2005) 1421-1428.
  • [9] H. Larhrib, X.M. Zeng, G.P. Martin, C. Marriott, J. Pritchard, The use of different grades of lactose as a carrier for aerosolized salbutamol sulfate, International Journal of Pharmaceutics 191 (1999) 1-14.
  • [10] P. Lucas, K. Anderson, J.N. Staniforth, Protein deposition from dry powder inhalers: fine particle multiplets as performance modifiers, Pharmacological Research 15 (1998) 562-569.
  • [11] R.J. Malcolmson, J.K. Embleton, ,Dry powder formulations for pulmonary delivery, Pharmaceutical Science and Technology 1 (1998) 394-398.
  • [12] K.B. Prinn, H.R. Costantino, M.Tracy, Statistical modeling of protein spray drying at the lab scale, AAPS Pharmaceutical Science and Technology 3 (2002) 1-8.
  • [13] M. Sakagami, W. Kinoshita, K. Sakon, J. Sato, Y. Makino, Mucoadhesive beclomethasone microspheres for powder inhalation: their pharmacokinetics and pharmacodynamics evaluation, Journal of Controlled Release 80 (2002) 207-218.
  • [14] M. Sasaki, N. Kato, H. Watanabe, H. Yamada, Silk protein, sericin, suppresses colon carcinogenesis induced by 1,2-dimethylhydrazine in mice, Oncology Reports 7 (2000) 1049-1052.
  • [15] M. Sasaki, H. Watanabe, N. Kato, Supplemental silk protein, sericin, suppresses colon tumorigenesis in 1, 2-dimethylhydrazine-treated mice by reducing oxidative stress and cell proliferation, Bioscience Biotechnology and Biochemistry 65 (2001) 2181-2186.
  • [16] K. Stahl, M. Claesson, P. Lilliehorn, H. Linden, K. Backstrom, The effect of process variables on the degradation and physical properties of spray dried insulin intended for inhalation, International Journal of Pharmaceutics 233 (2002) 227-237.
  • [17] Y. Tamada, Anticoagulant and its production Japan Patent 09-227402A, 1997.
  • [18] R. Thiering, F. Dehghani, A. Dillow, N.R. Foster, The influence of operating conditions on the dense gas precipitation of model proteins, Journal of Chemical Technology and Biotechnology 75 (2000) 29-41.
  • [19] X.M. Zeng, G.P Martin, C. Marriott, J. Pritchard, The influence of carrier morphology on drug delivery by dry powder inhalers, International Journal of Pharmaceutics 200(2000) 93-106.
  • [20] X.M. Zeng, G.P. Martin, C. Marriott, J. Pritchard, Lactose as a carrier in dry powder formulations: the influence of surface characteristics on drug delivery, Journal of Pharmaceutical Scences 90 (2001) 1424-1434.
  • [21] Y.Q Zhang, Application of natural silk sericin protein in biomaterials, Biotechnology Advances 20 ( 2002) 91-100.
  • [22] Y.Q. Zhang, M.L. Tao, W.D. Shen, J.P. Mao, Y. Chen, Synthesis of silk sericin peptides–Lasparaginase bioconjugates and their characterization, Journal of Chemical Technology and Biotechnology 81 (2006) 136-145.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BOS4-0021-0031
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