The influence of the environment on the degradation of polylactides and their composites

• Autorzy: Chłopek J. , Morawska-Chochół A. , Szaraniec B.
• Języki publikacji: EN

Abstrakty

EN

Purpose: The aim of this paper was to determine the influence of environment on degradation process of polylactide-based materials assigned for the implementation in medical implants and short-life products. The hydrolytic degradation, the biodegradation and the degradation under in vivo conditions were determined for the polylactide (PLA), the lactide and glycolide copolymer (PGLA) and the composites modified by hydroxyapatite particles, carbon fibres and natural fibres (hemp, jute). Design/methodology/approach: The degradation was analyzed on the basis of the changes occurring in the environment (such as those in pH fluids), the changes of the mass and resistance of the examined materials, as well as the structural infrared analyses. Findings: It was stated that the degradation time depends on the type of the environment with which the material is in contact. In the water environment, the degradation is faster than in the presence of a compost, and in the Ringer fluid, its speed is higher than in the artificial serum SBF. The in vitro observations focus mainly on the chemical interaction between the examined materials and the artificial environment. The degradation speed is dependent, among others, on the viscosity of the applied fluids and thus, their ability of penetration in the polymer’s structure and on the interfacial boundaries. In a living organism, the fundamental role is played by such processes as the protein adsorption, the cellular and tissue reactions, the body fluid flows and the charge exchanges, and thus, the degradation process is significantly faster than that under in vitro conditions. Practical implications: Result of this study can be used to elaborate the manufacturing method of implants with controlled resorption time and degradable short life time products like packages. Originality/value: In this paper effect of hydrolytic degradation, biodegradation and in vivo degradation on polymers’ and composites’ behaviour was shown. Result of this study can be used to prognosis of durability of degradable materials.

Słowa kluczowe

EN

polylactide; composite; degradation; fibers; FTIR

PL

poliaktyd; kompozyt; degradacja; włókna; FTIR

• Wydawca: International OCSCO World Press
• Czasopismo: Journal of Achievements in Materials and Manufacturing Engineering
• Rocznik: 2010
• Tom: Vol. 43, nr 1
• Strony: 72--79
• Opis fizyczny: Bibliogr. 22 poz., rys., tabl.

Twórcy

autor

Chłopek J.

autor

Morawska-Chochół A.

autor

Szaraniec B.

• Department of Biomaterials, Faculty of Materials Science and Ceramics, AGH – University of Science and Technology, Al. Mickiewicza 30, 30-059 Kraków, Poland,

Bibliografia

• [1] C. Nyambo, A.K. Mohanty, M. Misra, Polylactide-Based Renewable Green Composites from Agricultural Residues and Their Hybrids. Biomacromolecules 11 (2010) 1654-1660.
• [2] A.A. Shah, F. Hasan, A. Hameed, S. Ahmed, Biological degradation of plastics: A comprehensive review. Biotechnology Advances 26 (2008) 246-265.
• [3] G. Kalea, R. Aurasa, S.P. Singha, R. Narayan, Biodegradability of polylactide bottles in real and simulated composting conditions. Polymer Testing, 26 (2007) 1049-1061.
• [4] J.C. Middleton, A.J. Tipton, Synthetic biodegradable polymers as orthopedic devices, Biomaterials 21 (2000) 2335-2346.
• [5] L.S. Nair, C.T. Laurencin, Biodegradable polymers as biomaterials, Prog Polym Sci 32 (2007) 762-794.
• [6] M. Wang, Developing bioactive composite materials for tissue replacement, Biomaterials 24 (2003) 2133-2151.
• [7] R. Vanderby, P.P. Provenzano, Collagen in connective tissue: from tendon to bone, Journal of Biomechanics 36 (2003) 1523-1527.
• [8] A.R. Boccaccini, J.J. Blaker, V. Maquet, R.M. Day, R. Jérôme, Preparation and characterisation of poly(lactide-co-glycolide) (PLGA) and PLGA/BioglassR composite tubular foam scaffolds for tissue engineering applications, Materials Science and Engineering C25 (2005) 23-31.
• [9] S. Teixeira, M.H. Fernandes, M.P. Ferraz, F. Monteiro, Ad-hesion and Proliferation of human bone marrow cells on hydroxyapatite and hydroxyapatite/collagen porous scaffolds for bone tissue engineering, Proceedings of the 8th World Biomaterials Congress, Amsterdam, 2008, 1138.
• [10] N. Ashammakhi, P. Rokkanen, Absorbable polyglycolide devices in trauma and bone surgery, Biomaterials 18 (1997) 3-9.
• [11] S. Gogolewski, Bioresorbable polymers in trauma and bone surgery, Injury 31, Supplement 4 (2000) D28-D32.
• [12] M. Vert, Biodegradable aliphatic polyesters with respect to temporary therapeutic applications, in: Biomaterials, Hard Tissue Repair and Replacement, Muster D. ed., Elsevier Science Publisher, The Netherlands, 1992, 223-233.
• [13] R.A. Miller, J.M. Brady, D.E. Cutright, Degradation rates of oral resorbable implants (polylactates and polyglycolates): rate modification with changes in PLA/PGA copolymer ratios, Journal of Biomedical Materials Research 11 (1977) 711-719.
• [14] P. Dobrzyński, J. Kasperczyk, H. Janeczek, Synthesis of Biodegradable Copolymers with the Use of Low Toxic Zirconium Compounds. 1. Copolymerization of Glycolide with L-Lactide Initiated by Zr(Acac)4, Macromolecules 34 (2001) 5090-5099.
• [15] K. Haberko, M. Bućko, M. Haberko, W. Mozgawa, A. Pyda, J. Zarębski, Natural hydroxyapatite – preparation, properties, Eng. Biomat. 30-33 (2003) 32-38.
• [16] B. Szaraniec, T. Goryczka, Degradation of PLA/hemp and PLA/jute composites, Modern Polymeric Materials for Environmental Applications 4 (2010) (in press).
• [17] J. Chlopek, A. Morawska-Chochol, C. Paluszkiewicz, J. Jaworska, J. Kasperczyk, P. Dobrzynski, FTIR and NMR study of poly(lactide-co-glycolide) and hydroksyapatite implant degradation under in vivo conditions, Polymer Degradation and Stability 94 (2009) 1479-1485.
• [18] J. Chłopek, A. Morawska-Chochół, Cz. Paluszkiewicz, FTIR evaluation of PGLA – carbon fibres composite behaviour under ‘in vivo’ conditions, Journal of Molecular Structure 875 (1-3) (2008) 101-107.
• [19] A. Morawska-Chochół, J. Chłopek, A. Wietecha, Mechanical properties of polylactide modified with fibres and particles for intramedullary nails, Engineering of Biomaterials 99-101 (2010) 117-120.
• [20] J. Chłopek, A. Morawska, L. Umańska, C. Paluszkiewicz, The “in vitro” study of degradation process in composites made of resorbable polymers, Engineering of Biomaterials 38-42 (2004) 132-136.
• [21] I. Grizzi, H. Garreau, S. Li, M. Vert, Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence, Biomaterials 16 (1995) 305-311.
• [22] S. Li, S. McCarthy, Further investigations on the hydrolytic degradation of poly (DL-lactide), Biomaterials 20 (1999) 35-44.