HR TEM examinations of nanodiamond particles for biomedical application

• Autorzy: Mitura K.
• Języki publikacji: EN

Abstrakty

EN

Purpose: The aim of the study is an analysis of a different type of nano-diamond powders on HR TEM (material characterisation, the normal distribution of grain size). These nano-powders were used in many biological researches and each of them had a special biological activity. Comparison between the material and biological properties of diamond powders answered many questions about the chemical and physical reactions on a boundary: diamond surface – living organism. Design/methodology/approach: In this work we used cytotoxicity assays using MTT test and HR TEM examinations. We examined the nanodiamond particles manufactured by detonation method, RF/MW PACVD method, RF PACVD method, pure diamond from De Beers Company and graphite powder as a control. Findings: In this subject the material characterisation of diamond powders are known but we examined a different type of powders and we manufactured some of these nanopowders in our laboratory. Practical implications: Nanocrystalline Diamond Coatings have many applications in various fields of medicine. Nanodiamond Particles are an extended surface of diamond powder. Biological research with endothelial and lung cancer cells are the introduction to application in human’s treatment. Originality/value: There are in vitro examinations with bioactive biomaterial. Nanodiamond particles have a very high bioactivity on cell level and inhibit cancerogenesis.

Słowa kluczowe

EN

nanomaterials; HRTEM; nanodiamond particles; MTT test

PL

nanomateriały; HRTEM; cząsteczki nanodiamentu; test MTT

• Wydawca: International OCSCO World Press
• Czasopismo: Journal of Achievements in Materials and Manufacturing Engineering
• Rocznik: 2009
• Tom: Vol. 37, nr 2
• Strony: 317--322
• Opis fizyczny: Bibliogr. 12 poz., rys., tabl.

Twórcy

autor

Mitura K.

• Institute of Materials Science and Engineering, Technical University of Lodz, ul. Stefanowskiego 1/15, 90-924 Łódź, Poland,

Bibliografia

• [1] K. Bakowicz, Bioactivity of diamond, PhD thesis, Technical University of Lodz, Poland, 2003 (in Polish).
• [2] M. Czerniak-Reczulska, P. Niedzielski, A. Balcerczyk, G. Bartosz, A. Karowicz-Bilińska, K. Mitura, Biological properties of different type carbon particles in vitro study on primary culture of endothelial cells, Journal of Nanoscience and Nanotechnology 10 (2010) 1-7.
• [3] A. A Van de Loosdrecht, E. Nennie, G. J. Ossenkoppete, R. H. J. Bcelen, M. M. A. C. Langenhuijsen, Cell mediated cytotoxicity against U 937 cells by human monocytes and macrophages in a modified colorimetric MTT assay: A methodological study, Journal of Immunological Methods 141/1 (1991) 15-22.
• [4] A. Balcerczyk, M. Soszynski, D. Rybaczek, T. Przygodzki, A. Karowicz-Bilińska, J. Maszewski, G. Bartosz, Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium, Biochemical Pharmacology 69/8 (2005) 1263-1273.
• [5] Y. Manabe, T. Sugimoto, T. Kawasaki, M. Uedaa, Nanometre-scale direct observation of the receptor for the leaf-movement factor in plant cell by a novel TEM probe, Tetrahedron Letters 48 (2007) 1341-1344.
• [6] S. Mitura, K. Mitura, P. Niedzielski, P. Louda, V. Danilenko, Nanocrystalline Diamond, its synthesis, properties and applications, Journal of Achievements in Materials and Manufacturing Engineering 16 (2006) 9-16.
• [7] Y. Gogotsi (ed.), Carbon Nanomaterials, Taylor and Francis Group, LLC, 2006.
• [8] S. Mitura, Nanodiamonds, Journal of Achievements in Materials and Manufacturing Engineering 24/1 (2007) 166-171.
• [9] W. Kaczorowski, Carbon coatings deposited by MW/RF plasma method, PhD Thesis, Technical University of Lodz, Poland, 2005 (in Polish).
• [10] B. E. Sumpio, J. T. Riley, A. Dardik, Cells in focus: endothelial cell, Cell Biology 34 (2002) 1508-1512.
• [11] K. Mitura, P. Niedzielski, G. Bartosz, J. Moll, B. Walkowiak, Z. Pawłowska, P. Louda, M. Kieć-Świerczyńska, S. Mitura, Interactions between carbon coatings and tissue, Surface Coatings Technology 201 (2006) 2117-2123.
• [12] S. K. Alpard, J. B. Zwischenberger, Staging and surgery for non-small cell lung cancer (NSCLC), Surgical Oncology 7 (1999) 25-43.