Spray drying as a method of producing silk sericin powders

• Autorzy: Genç G. , Narin G. , Bayraktar E.
• Języki publikacji: EN

Abstrakty

EN

Purpose: The purpose of paper is to analyse Spray drying as a method of producing silk sericin powders. Design/methodology/approach: Aqueous sericin solutions were used as raw material for the production of dry powders using a lab-scale spray dryer. A linear regression analysis of agglomeration was employed, in addition to experimental designs at two levels with three factors for the analysis of three responses: moisture content, particle type and agglomeration degree. The process factors were the drying air temperature (120şC and 160şC), the feed rate (1.25 × 10-7 and 2.5 × 10-7 mł/s), and the concentration of sericin solutions of 10% and 30% (w/w) fed to the spray dryer. Findings: The three responses were analyzed statistically to determine the effective parameters and it was concluded that moisture content depended on three factors--drying air temperature being the dominant parameter. Particle size and shape depended mainly on feed rate and agglomeration depended on the moisture content of the product. Practical implications: As a result of the growing interest in drug delivery through a pulmonary route for local and systemic effects, the crucial physical characteristics of the spray-dried sericin influencing the dispersion and deposition behaviour including particle size, morphology, moisture content and agglomeration degree were examined for formulation and spray drying variables. Originality/value: The most effective parameters on particle size and morphology were found to be the feed solution concentration and feed rate, while the temperature was an insignificant variable.

Słowa kluczowe

EN

spray drying; sericin; pulmonary; drug delivery

PL

suszenie natryskowe; serycyna; układ oddechowy; dostarczanie leków

• Wydawca: International OCSCO World Press
• Czasopismo: Journal of Achievements in Materials and Manufacturing Engineering
• Rocznik: 2009
• Tom: Vol. 37, nr 1
• Strony: 78--86
• Opis fizyczny: Bibliogr. 22 poz., rys., tabl.

Twórcy

autor

Genç G.

autor

Narin G.

autor

Bayraktar E.

• Chemical Engineering Department, Izmir Institute of Technology, Izmir, 35430, Turkey,

Bibliografia

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