Separation of fudosteine on an achiral C 18 column by HPLC with chiral ligand-exchange selectors as mobile phase additives

• Autorzy: Ma J. , Cao J. , Ding M. J. , Yuan L. H. , Zhai M. J. , Zhang J. , Zhang Q. , Li F. , Zhou X. M.
• Języki publikacji: EN

Abstrakty

EN

A reversed-phase chiral liquid chromatographic method had been developed and validated for resolution of the enantiomers of racemic fudosteine. The effects on the separation of the amounts of anhydrous cupric sulfate and _L -phenylalanine, the methanol content, mobile phase pH, and temperature were investigated. The method was validated for linearity, repeatability, intermediate precision, sample recovery, solution stability, and limits of detection (LOD). _L -Phenylalanine and anhydrous cupric sulfate as chiral ligand-exchange complexes were used for separation, isomer identification, related substance investigation, and analysis of fudosteine enantiomers in fudosteine bulk drugs and fudosteine tablets.

Słowa kluczowe

EN

chiral ligand-exchange additives; L-fudosteine; HPLC

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2008
• Tom: Vol. 20, no. 4
• Strony: 585--594
• Opis fizyczny: Bibliogr. 15 poz., rys., tab.

Twórcy

autor

Ma J.

autor

Cao J.

autor

Ding M. J.

autor

Yuan L. H.

autor

Zhai M. J.

autor

Zhang J.

autor

Zhang Q.

autor

Li F.

autor

Zhou X. M.

• Nanjing Medical University School of Pharmacy Nanjing City 210029 P.R. China,

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