Simultaneous TLC-densitometric analysis of atenolol and lercanidipine hydrochloride in tablets

• Autorzy: Deore P. V. , Shirkhedkar A. A. , Surana S. J.
• Języki publikacji: EN

Abstrakty

EN

A new simple, precise, accurate, and selective thin-layer chromatographic (TLC) method has been developed for simultaneous analysis of atenolol and lercanidipine hydrochloride in a tablet dosage form. Chromatographic separation was achieved on aluminum foil plates precoated with silica gel 60F ₂₅₄ , with toluene-methanoltriethylamine 3.5:1.5:0.1 (v/v) as mobile phase. Detection was performed densitometrically at 275 nm. The R _F of atenolol and lercanidipine hydrochloride were 0.24 and 0.68, respectively. The reliability of the method was assessed by evaluation of linearity (2000-12000 ng per band for atenolol and 400-2400 ng per band for lercanidipine hydrochloride), accuracy (98.94 š 0.30% for atenolol and 99.75 š 0.69% for lercanidipine hydrochloride), and specificity, in accordance with ICH guidelines. The method can be used for routine simultaneous analysis of atenolol and lercanidipine hydrochloride in pharmaceutical formulations.

Słowa kluczowe

EN

atenolol; lercanidipine; hydrochloride; TLC-densitometry; simultaneous determination

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2008
• Tom: Vol. 20, no. 3
• Strony: 463--473
• Opis fizyczny: Bibliogr. 17 poz., rys., tab.

Twórcy

autor

Deore P. V.

autor

Shirkhedkar A. A.

autor

Surana S. J.

• R.C. Patel College of Pharmacy Department of Pharmaceutical Chemistry Shirpur Dist: Dhule (M.S.) India 425 405,

Bibliografia

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