Validated liquid chromatographic method for analysis of the isomers of latanoprost

• Autorzy: Widomski P. , Baran P. , Gołębiewski P. , Surowiec I. , Bielejewska A.
• Języki publikacji: EN

Abstrakty

EN

Baseline separation of latanoprost and its isomers 15(S)-latanoprost (impurity I) and 5,6-trans-latanoprost (impurity II) has been achieved for the first time by HPLC on an NH2 column with heptane-2-propanol-acetonitrile 93:6:1 (v/v), with addition of a small amount of water, as mobile phase. Validation of the method is described.

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2008
• Tom: Vol. 20, no. 2
• Strony: 157--164
• Opis fizyczny: Bibliogr. 14 poz., rys., tab.

Twórcy

autor

Widomski P.

autor

Baran P.

autor

Gołębiewski P.

autor

Surowiec I.

autor

Bielejewska A.

• Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland Pharmaceutical Research Institute, Rydygiera 8, 01-793 Warsaw, Poland E-mail: [e-mail]

Bibliografia

• [1] J. Stjernschantz and B. Resul, Drugs Fut., 17, 691 (1992)
• [2] B. Resul, J. Stjernschantz, K. No, Ch. Liljebria, G. Selen, M. Astin, M. Karlsson, and L.Z. Bito, J. Med. Chem., 36, 243 (1993)
• [3] S.F.E. Nilsson, M. Samuelsson, A. Bill, and J. Stjernschantz, Exp. Eye Res., 48, 707 (1989)
• [4] B. Sjőquist, S. Basu, K. Bergh, and P. Byding, Exp. Eye Res., 59, 146 (1994)
• [5] M. Abramovitz, M. Adam, Y. Boie, et al., Biochim. Biophys. Acta, 1483, 285 (2000)
• [6] Ch. Linden, E. Nuika, and A. Alm, Brit. J. Ophthalmol., 81, 370 (1997)
• [7] S. Nagasubramanian, G.P. Sheth, R.A. Hitchings, and J. Stjernschantz, Ophthalmology, 100, 1305 (1993)
• [8] Impurities in New Drug Substances. Q3A (R1), International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use
• [9] A.R. Whorton, K. Carr, M. Smigel, L. Walker, K. Ellis, and J.A. Oates, J. Chromatogr. 163, 64 (1979)
• [10] S. Ahuja, Selectivity and Detectability Optimization in HPLC, John Wiley and Sons, New York, 1989
• [11] S.M. Plaised, T.A. Zwier, and B.G. Snider, J. Chromatogr., 281, 151 (1983)
• [12] V. Radulescu, C. Doneanu, C. Mandruta, and F. Cocu, Rev. Roum. Chim., 42, 1129 (1997)
• [13] M. Ashfaq, I.U. Khan, and M.N. Asghar, Anal. Lett., 39, 2235 (2006)
• [14] P.V. Morgan, S. Proniuk, J. Blanchard, and R.J. Noecker, J. Glaucoma, 10, 401 (2001).