Chiral high-performance liquid chromatographic method for enantioselective analysis of zaltoprofen

• Autorzy: Nirogi R. V. S. , Kota S. , Peruri B. G. , Kandikere V. N. , Mudigonda K.
• Języki publikacji: EN

Abstrakty

EN

A simple reversed-phase chiral HPLC method has been developed and validated for direct separation of the enantiomers of zaltoprofen. Separation of the enantiomers was tested on numerous commercial chiral HPLC columns. Separation was best (resolution, RS = 3) on a Chiralcel OJ-RH stationary phase. Typical retention times of the S and R enantiomers were approximately 14 and 16 min, respectively. Mobile phase composition was systematically studied to find the optimum chromatographic conditions. Validation of the method under the conditions selected showed it was selective and precise and the detector response was a linear function of zaltoprofen enantiomer concentration.

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2006
• Tom: No. 17
• Strony: 202--209
• Opis fizyczny: Bibliogr. 13 poz., rys., tab.

Twórcy

autor

Nirogi R. V. S.

autor

Kota S.

autor

Peruri B. G.

autor

Kandikere V. N.

autor

Mudigonda K.

• Suven Life Sciences Ltd, Serene Chambers, Road # 7, Banjara Hills, Hyderabad-500034, India

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