A simple and sensitive TLC method for determination of clopidogrel and its impurity SR 26334 in pharmaceutical products

• Autorzy: Antić D. , Filipić S. , Agbaba D.
• Języki publikacji: EN

Abstrakty

EN

A simple, conventional TLC method has been established for separation of clopidogrel and its hydrolytic product SR 26334, the main impurity in clopidogrel. Use of aluminium foil-backed silica gel 60F254 plates with n-heptane–tetrahydrofuran, 1:1 (v/v), as mobile phase, enabled successful separation of clopidogrel in high excess from the impurity. The separated compounds were detected at 230 nm. Regression coefficients (r ≥ 0.999), recovery (94.5–107.1%), and limit of quantification (0.047 mg mL-1) were evaluated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of clopidogrel both in raw material and in dosage forms.

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2007
• Tom: No. 18
• Strony: 199--206
• Opis fizyczny: Bibliogr. 13 poz., rys., tab.

Twórcy

autor

Antić D.

autor

Filipić S.

autor

Agbaba D.

• Institute of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia

Bibliografia

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