Application of RP-HPLC-ED assay to analysis of the blood of Parkinson's disease patients

• Autorzy: Głód B. K. , Stańczak K. I.
• Języki publikacji: EN

Abstrakty

EN

Results from application of reversed-phase HPLC with electroche-mical detection to analysis of catecholamines and total antioxidant poten-tial are presented. The assay was used to estimate their daily profiles in blood serum of patients treated with anti-Parkinson drugs. It was found that increases in the concentration of hydroxy radicals in blood serum, and of the total antioxidant potential related to the hydroxy radical, was inversely correlated with the concentration of catecholamines in the serum. This sug-gests that catecholamines are pro-oxidants of hydroxy radicals. The method also enabled us to study changes in the concentrations of catecholamines during their storage at room temperature. It was found that change of drug color was caused by the oxidation of benseraside.

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2005
• Tom: No. 15
• Strony: 276--288
• Opis fizyczny: Bibliogr. 39 poz., rys., tab.

Twórcy

autor

Głód B. K.

• Meat and Fat Research Institute, Jubilerska 4, 04-190 Warsaw, Poland

autor

Stańczak K. I.

• Medical Research Centre, Polish Academy of Sciences, Pawińskiego 5, 03-187 Warsaw, Poland

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