High-performance liquid chromatographic determination of isoniazid, pyrazinamide, and indomethacin in pharmaceutical preparations

• Autorzy: Khuhawar M. Y. , Rind F. M. A. , Rajper A. D.
• Języki publikacji: EN

Abstrakty

EN

Isoniazid (INH) has been quantitated after precolumn derivatization with 5-methylfuran-2-carboxaldehyde (MFA). Chromatography was performed on a 150 mm × 4.6 mm i.d. YMC-ODS column with water–methanol–tetrahydrofuran, 59:39:2 (v/v) as a mobile phase at a flow rate of 2 mL min-1. Detection was performed at 328 nm. By adoption of this proc-dure pyrazinamide (PZA) and indomethacin (IM) separated completely and could be determined together with INH. Linear calibration plots were obtained between 1.4 and 5.5 µg mL-1 for INH, between 6.2 and 30.8 µg mL-1 for PZA, and between 10.7 and 64.08 µg mL-1 for IM. The method of analysis was used for quantitation of INH, PZA, and IM in pharmaceutical preparations with a coefficient of variation <1%.

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2005
• Tom: No. 15
• Strony: 269--275
• Opis fizyczny: Bibliogr. 25 poz., rys., tab.

Twórcy

autor

Khuhawar M. Y.

• Dr M.A. Kazi Institute of Chemistry, University of Sindh, Jamshoro, Pakistan

autor

Rind F. M. A.

• Dr M.A. Kazi Institute of Chemistry, University of Sindh, Jamshoro, Pakistan

autor

Rajper A. D.

• Dr M.A. Kazi Institute of Chemistry, University of Sindh, Jamshoro, Pakistan

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