Estimation of antioxidative properties of phenylacetic acids using ion-exclusion chromatography

• Autorzy: Głód B. K. , Grieb P.
• Języki publikacji: EN

Abstrakty

EN

Cellular oxidative stress has been implicated as a key mechanism of cell differentiation provoked by several compounds (doxorubicins, fibrades, edelfosine). Phenylacetate and its derivatives in submillimolar to millimolar concentrations induce cell differentiation. Ion-exclusion chromatography is widely used for separation and analysis of weak acids. We applied it to the analysis of phenylacetic acids and to the determination of the hydroxyl radical-trapping potential of some of these compounds. Their total antioxidant potential for peroxy radicals was also measured using a photometric method. It was found that phenylacetates are weak antioxidants and in the concentrations which induce cell differentiation effects may substantially reinforce intracellular antioxidative potential.

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2005
• Tom: No. 15
• Strony: 258--268
• Opis fizyczny: Bibliogr. 34 poz., rys.

Twórcy

autor

Głód B. K.

• Meat and Fat Research Institute, Jubilerska 4, 04-190 Warsaw, Poland

autor

Grieb P.

• Medical Research Center, Polish Academy of Sciences, Laboratory of Experimental Pharmacology, ul. Pawińskiego 5, 03-187 Warszawa, Poland

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