Tytuł artykułu
Autorzy
Wybrane pełne teksty z tego czasopisma
Identyfikatory
Warianty tytułu
Języki publikacji
Abstrakty
Separation of the enantiomers of linezolid has been compared on derivatized cellulose and amylose chiral stationary phases (Chiracel OD and Chiralpak AD) with mixtures of hexane with 1-propanol, 2-propanol, or ethanol as mobile phases. It was found that use of a small amount of water as mobile phase additive can improve or prevent enantioseparation, depending on the column. The order of elution of the linezolid enantiomers was different on the Chiracel OD and Chiralpak AD columns, and baseline resolution was achieved on the Chiralpak AD column only. Reversal of the order of elution of the enantiomers on changing from the propanols to ethanol was observed on both columns. The effect of temperature (in the narrow range 15–35°C) on retention and enantioselectivity was studied for both columns and a variety of mobile phases. The standard enthalpy (ΔH°) and entropy (ΔS°) changes for solute transfer between the mobile and sta-tionary phases were also estimated.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Strony
183--191
Opis fizyczny
Bibliogr. 13 poz., rys., tab.
Twórcy
autor
- Institute of Physical Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland
- Pharmaceutical Research Institute, Rydygiera 8, 02-187 Warsaw, Poland
autor
- Institute of Physical Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland
autor
- GlaxoSmithKline, Analyt Chem, Harlow CM19 5AD, Essex, England
Bibliografia
- [1] S.M. Swaney, H. Aoki, M.C. Ganoza, and D.L. Shinabarger, Antimicrob. Agents Chemother., 42, 3251 (1998)
- [2] M. Ehrlich, R. Trittler, F.D. Daschner, and K. Kummerer, J. Chromatogr. B, 755, 373 (2001)
- [3] Y. Okamoto and Y. Kaida, J. Chromatogr. A, 666, 403 (1994)
- [4] Y. Okamoto and E. Yashima, Angew. Chem., Int. Ed. Eng., 73, 1020 (1998)
- [5] M. Okamoto, J. Pharm. Biomed. Anal., 27, 401 (2003)
- [6] T Wang and Y.W. Chen, J. Chromatogr. A, 855, 411 (1999)
- [7] T Wang, Y.W. Chen, and A. Vailaya, J. Chromatogr. A, 902, 345 (2000)
- [8] J. Dingenen, Polysaccharide Phases in Enantioseparations, in: G Subramanian (ed.). A Practical Approach to Chiral Separation by Liquid Chromatography, VCH, Weinheim, 1994, p. 115
- [9] J.G. Ning, Enantiomer, 5, 323 (2000)
- [10] K. Balmer, P.O. Lagerstrom, B.A. Persson, and G. Schill, J. Chromatogr., 592, 331 (1992)
- [11] C. Narayana, T. Suresh, S.M. Rao, P.K. Dubey, and J.M. Babu, J. Pharm. Biomed. Anal., 32, 21 (2003)
- [12] H. Koller, K.H. Rimbock, and A. Mannschreck, J. Chromatogr., 282, 89 (1983)
- [13] J. Chmielowiec and H. Sawitzky, J. Chromatogr. Sci., 17, 245 (1979)
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BAT3-0028-0078