High-performance liquid chromatography separation of glycerol derivatives on a chiral stationary phase

• Autorzy: Bugla J. , Wandzik I. , Szeja W.
• Języki publikacji: EN

Abstrakty

EN

We report herein the separation of enantiomers of glycerol derivatives on a cellulose-modified chiral column (Chiracel OD) in normal-phase mode. This method is suitable for monitoring the progress of the reaction and for determination of the enantiomeric purity of products. The lipase Novozyme 435-catalysed enantioselective hydrolysis of 1-O-benzyl-2,3-di-O-octanoyl-rac-glycerol has been shown to be an efficient method for preparation of 1-O-benzyl-2-O-octanoyl-sn-glycerol with high enantiomeric excess (ee > 95%).

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2005
• Tom: No. 15
• Strony: 173--182
• Opis fizyczny: Bibliogr. 25 poz., rys., tab.

Twórcy

autor

Bugla J.

• Silesian University of Technology, Faculty of Chemistry, Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, 44-100 Gliwice, Krzywoustego 4, Poland

autor

Wandzik I.

• Silesian University of Technology, Faculty of Chemistry, Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, 44-100 Gliwice, Krzywoustego 4, Poland

autor

Szeja W.

• Silesian University of Technology, Faculty of Chemistry, Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, 44-100 Gliwice, Krzywoustego 4, Poland

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