Resolution of the diastereoisomers of prednisolone tetrahydrophthalate by chromatographic methods

• Autorzy: Olszewska E. , Kroszczyński W. , Łypacewicz M. , Wasiak T.
• Języki publikacji: EN

Abstrakty

EN

The tetrahydrophthalic ester of prednisolone C29H36O8, which is used as a anti-inflammatory drug, consists of two diastereoisomers. This paper describes the effect of addition of optically active compounds (amino acids, cyclodextrin, camphosulphonic acid) on the capacity ratios, k', and separation factors, ?, of these diastereoisomers in TLC and HPLC.

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2002
• Tom: No. 12
• Strony: 219--225
• Opis fizyczny: Bibliogr. 8 poz., tab.

Twórcy

autor

Olszewska E.

• Institute of Chemistry, University of Podlasie, 3 Maja Street 54, 08-110 Siedlce, Poland

autor

Kroszczyński W.

• Institute of Chemistry, University of Podlasie, 3 Maja Street 54, 08-110 Siedlce, Poland

autor

Łypacewicz M.

• Institute of Pharmaceutical Industry, Rydygiera Street 8, 01-793 Warsaw, Poland

autor

Wasiak T.

• Institute of Pharmaceutical Industry, Rydygiera Street 8, 01-793 Warsaw, Poland

Bibliografia

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• [3] M. Krstulovic, Chiral Separations by HPLC, Ellis Harwood, Chichester, 1989
• [4] S. G. Allenmark, Chromatographic Enantioseparation, Ellis Harwood, Chichester, 1988
• [5] R. Bhushan and I. Ali, Chromatographia, 23, 141 (1987)
• [6] M. Remelli, R. Piazza, and F. Pulidori, Chromatographia, 32, 278 (1991)
• [7] A. Wettstein and L. Ehemann, DBP 1122951 (1962); Chem. Abs., 57, 5990b (1962)
• [8] W. L. Duax and D. A. Norton, Atlas of Steroid Structures, Vol. I, Plenum, New York, 1975