Analysis of carisoprodol tablets by HPTLC with visible absorbance densitometry

• Autorzy: Fisher J. , Sherma J.
• Języki publikacji: EN

Abstrakty

EN

A high-performance thin-layer chromatographic method has been developed for the quantitative determination of the muscle relaxant carisoprodol (Soma) in tablets. Chromatography was on silica gel plates with inorganic binder, detection by charring with sulfuric acid-methanol reagent, and quantification by densitometric scanning of zones of samples and standards. The method was applied to tablets containing carisoprodol as the only active ingredient and to tablets containing carisoprodol with aspirin and with aspirin plus codeine phosphate. Tablets were analyzed and the results compared with the label declarations; all results were within the š10% range specified in the US Pharmacopeia. Accuracy was validated by recovery from a blank sample spiked with a known concen-tration of carisoprodol and by standard addition analysis of a carisoprodol tablet solution before and after spiking to double its label content; errors for both methods were below 1.0%. Precision (RSD) was 1.0% for a sample analyzed four times on separate plates.

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2001
• Tom: No. 11
• Strony: 96--101
• Opis fizyczny: Bibliogr. 6 poz., rys.

Twórcy

autor

Fisher J.

autor

Sherma J.

• Department of Chemistry, Lafayette College, Easton, PA 18042, USA