Thin-layer chromatographic estimation of the lipophilicity of some metallic complexes of diclofenac with potential anti-inflammatory activity

• Autorzy: Sârbu C. , Demertzis M. A. , Kovala-Demertzi D.
• Języki publikacji: EN

Abstrakty

EN

The relative lipophilicity of seven complexes of diclofenac sodium {[2-[(2,6-dichlorophenyl)amino]phenyl]acetate}, NaL, with Cu2+, Co2+, Ni2+, Mn2+, Fe3+, Fe2+ and Pd2+, with potential anti-inflammatory properties, have been determined by reversed-phase thin-layer chromatography on C18 and CN plates with water–methanol mixtures as mobile phases. The RF values of the compounds increased linearly with increasing concentra-tion of methanol in the mobile phase. Generally, the presence of a cation increases the lipophilicity, expressed as the intercept (RM0), in the same manner. This means that the lipophilic behavior of metallic complexes depends primarily on the structure of ligand, although a more lipophilic effect was observed for Fe2+, Ni2+ and Fe3+ on C18 plates and for Cu2+ and, again, Fe2+ and Pd2+ on CN plates.

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2000
• Tom: No. 10
• Strony: 222--230
• Opis fizyczny: Bibliogr. 41 poz., rys., tab.

Twórcy

autor

Sârbu C.

autor

Demertzis M. A.

autor

Kovala-Demertzi D.

• Faculty of Chemistry and Chemical Engineering, Department of Analytical Chemistry, ‘Babeş-Bolyai’ University, Arany Janos 11, RO-3400 Cluj-Napoca, Romania