Determination by SPE - HPLC of ionized and non-ionized fractions of free carbamazepine and its metabolites carbamazepine-10,11-epoxide and 10,11-trans-dihydroxycarbamazepine

• Autorzy: Pieniak M. , Kowalczyk M.
• Języki publikacji: EN

Abstrakty

EN

A fast, simple and accurate SPE-HPLC method has recently been developed for simultaneous determination of the ionized and non-ionized fractions of carbamazepine (CBZ) and its main metabolites carbamazepi-ne-10,11-epoxide (CBZ-10,11-E) and carbamazepine-10,11-trans-dihy-droxycarbamazepine (CBZ-10,11-D). This study has determined the influence of pH on the ratio of the ionized to non-ionized forms of these compounds. The usefulness of the method for therapeutic monitoring of anti-epileptic drugs was also evaluated.

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 1998
• Tom: No. 8
• Strony: 108--113
• Opis fizyczny: Bibliogr. 7 poz., tab.

Twórcy

autor

Pieniak M.

autor

Kowalczyk M.

• Department of Pharmacology and Toxicology, Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Kozielska 4, Poland