Correlated mutations in selected protein families

• Autorzy: Leluk J. , Sobczyk M. , Becella Ł.
• Konferencja: 8th Workshop of the Polish Society of Computer Simulation (30.08-1.09.2001, Gdańsk-Sobieszewo, Poland)
• Języki publikacji: EN

Abstrakty

EN

Four different protein families (two proteinase inhibitor families, myoglobins and lysozymes) were surveyed for correlated mutations with respect to the position distance and their significance in structure stabilization and biological activity. They were chosen for this study in order to verify the currently admitted model of mutational correlation relationship with respect to spatial contact of the residues and contribution in protein biological activity. There was observed high contribution of spatially dispersed residues (which are also not involved in the protein active center) in mutational correlation. Because of the significantly large distance between correlated positions these cases do not correspond explicitly to any mechanism included in current hypotheses. It is suggested that the role of residue spatial contact in structure preservation, intermolecular interaction and active site rescue mechanisms only partially explains the correlation phenomenon.

Słowa kluczowe

EN

protein sequence; multiple alignment; tertiary structure; mutational correlation; genetic semihomology algorithm

• Wydawca: Politechnika Gdańska
• Czasopismo: TASK Quarterly : scientific bulletin of Academic Computer Centre in Gdansk
• Rocznik: 2002
• Tom: Vol. 6, No 3
• Strony: 469--482
• Opis fizyczny: Bibliogr. 16 poz., rys.

Twórcy

autor

Leluk J.

• Institute of Biochemistry and Molecular Biology, University of Wroclaw, Tamka 2, 50-137 Wroclaw, Poland
• Interdisciplinary Centre of Mathematical and Compytational Modeling (ICM), University of Warsaw, Powińskiego 5A, 02-106 Warsaw, Poland

autor

Sobczyk M.

• Institute of Biochemistry and Molecular Biology, University of Wroclaw, Tamka 2, 50-137 Wroclaw, Poland

autor

Becella Ł.

• Institute of Biochemistry and Molecular Biology, University of Wroclaw, Tamka 2, 50-137 Wroclaw, Poland

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