Wpływ nurkowania na PAI - 1 I ALFA2-antyplazminy oraz aktywność fibrynolityczna

• Autorzy: Radziwon P. , Olszański R. , Tomaszewski R. , Lipska A. , Dąbrowiecki Z. , Korzeniewski K. , Siermontowski P. , Boczkowska-Radziwon B

Warianty tytułu

EN

Decreased levels of PAI-1 and alpha2-antiplasmin contribute to enhanced fibrynolitic activity in divers

• Języki publikacji: PL

Abstrakty

PL

Praca mówi o nie zbadanych dotychczas dokładnie powiązaniach choroby dekompresyjnej z zagadnieniami hemostazy a szczególnie fibrynolizy. Badany był wpływ ekspozycji hiperbarycznej na główne składniki systemu fibrynolizy. Dwie grupy młodych mężczyzn poddawane były ekspozycjom hierbarycznym do ciśnienia 400 kPa - grupa I - i 700 kPa - grupa II. Stosowano dekompresję powietrzna. Po ekspozycji badano nurków na obecność objawów choroby dekompresyjnej, a także poszukiwano pęcherzyków gazu w naczyniach żylnych metoda Dopplera. 15 minut po zakończeniu dekompresji pobierano krew do badań koagulologicznych. Badano stężenie i aktywność t-PA i PAI-1, stężenie PAP i alfa2-antyplazminy. W grupach badawczych nie stwierdzono wykładników choroby dekompresyjnej ani nadmiernej ilości pęcherzyków wewnątrznaczyniowych. Stwierdzono miedzy innymi spadek poziomu alfa2-antyplazminy, spadek stężenia i aktywności PAI-1. Nie zaobserwowano zmian w zakresie czynnika XII jak i t-PA. Ekspozycja hiperbaryczna i dekompresja indukuje fibrynolize, nawet bez obecności pęcherzyków gazowych.

EN

There are a number of reported cases of decompression sickness (DCS) with haemorrhages. These cases have not been sufficiently investigated and thus bleeding complications could not be directly correlated to the enhanced fibrinolysis. The effect of hyperbaric exposition and decompression on the main components of fibrynolitic system have been measured. Two groups of 25 male divers each, were subjected to hyperbaric exposures to the pressure of either 400 kPa - group I - or 700 kPa - group II followed by a staged decompression. The divers were monitored for clinical symptoms of DCS and checked for Doppler-detected venous gas bubbles. Venous blood was drawn from divers before exposition and 15 minutes after decompression. The concentrations and activities of t-PA and PAI-1 as well as concentrations of PAP and alpha2-antiplasmin and activity of factor XIIa were measured. In all groups of divers no cases of DCS as well as detectable gas bubbles were noted. We observed elevated concentration of PAP, decreased concentration of alpha2-AP, decreased PAI-1 concentration and activity. There were no significant changes in factor XIIa activity as well a of t- PA concentration and activity. Hyperbaric exposition and decompression induce activation of fibrynolisis, even in the absence of detectable gas bubbles. Fibrynolitic activity increases mainly due to decrease of PAI-1 concentration and activity. Further clinical trials are necessary for the estimation of the importance of activation of fibrynolisis with decreased level of PAI-1 and alpha2-AP as possible risk factor for bleeding in divers.

Słowa kluczowe

PL

alfa2-antyplazmina; choroba dekompresyjna; PAI-1; PAP; t-PA

EN

alpha2-antiplasmin; decompression sickness; PAI-1; PAP; t-PA

• Wydawca: Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej
• Czasopismo: Polish Hyperbaric Research
• Rocznik: 2007
• Tom: Nr 3(20)
• Strony: 33--42
• Opis fizyczny: Bibliogr. 35 poz., tab.1, wykr.4

Twórcy

autor

Radziwon P.

autor

Olszański R.

autor

Tomaszewski R.

autor

Lipska A.

autor

Dąbrowiecki Z.

autor

Korzeniewski K.

autor

Siermontowski P.

autor

Boczkowska-Radziwon B

• Regional Centre for Transfusion Medicine, Skłodowskiej 23 PL - 15-950 Białystok, Poland,

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