Terapia fotodynamiczna (PDT) w chorobach skóry - co nowego?

• Autorzy: Kawczyk-Krupka A. , Ledwon A. , Karpe J. , Simon-Sieroń M. , Sieroń A.

Warianty tytułu

EN

Photodynamic therapy (PDT) in dermatology - what's new?

• Języki publikacji: PL

Abstrakty

PL

Poniższa praca prezentuje przegląd piśmiennictwa dotyczącego wskazań do leczenia fotodynamicznego w chorobach nowotworowych skóry, jak i prace prezentujące nowe możliwości zastosowania PDT także w nienowotworowych chorobach skóry. Udowodnione jest skuteczne leczenie z zastosowaniem terapii fotodynamicznej takich schorzeń, jak raki podstawnokomórkowe, choroba Bowena, rogowacenie słoneczne, powierzchowny rak kolczystokomórkowy, przerzuty raka piersi do skóry, ziarniniak grzybiasty oraz łuszczyca. Wykazano także, iż PDT z miejscową aplikacją kwasu 5-delta-aminolewulinowego (ALA) jest skuteczne w leczeniu epidermodysplazji brodawczakowatej, chorobie Dariera oraz w schorzeniach mikrobiologicznych, np. w kandidiazie. Nowym kierunkiem rozwoju PDT są wskazania kosmetyczne (odmładzanie skóry światłem). Wszystkie te wskazania związane są z selektywnym, bezpiecznym i skutecznym działaniem terapii fotodynamicznej.

EN

The study presents main medical indications of photodynamic therapy in skin neoplasm and new directions in the other, nonmalignant skin diseases. In dermatology PDT has been proven to be effective in the treatment of basal cell carcinomas (BCC), Bowen's disease, actinic keratoses, superficial squamous cell carcinomas (SCC), metastatic breast cancer, mycosis fungoides and psoriasis. It was also demonstrated that PDT with topical application of d-aminolevulinic acid (ALA) can selectively photosensitize other skin lesions, i.e.: epidermodysplasia verruciformis and affected skin areas in Darier's disease and microbiological infections (candidiasis). New approach of PDT is connected with cosmetic indication- photo-rejuvenation. These whole indications are connected with selective, safety and effective properties of PDT.

Słowa kluczowe

PL

terapia fotodynamiczna; choroby skóry; fotouczulacz; nowotwory

EN

photodynamic therapy; skin diseases; photosensitizer; neoplasms

• Wydawca: Górnośląska Wyższa Szkoła Pedagogiczna im. Kardynała Augusta Hlonda
• Czasopismo: Journal of Ecology and Health
• Rocznik: 2011
• Tom: R. 15, nr 1
• Strony: 28--34
• Opis fizyczny: Bibliogr. 37 poz.

Twórcy

autor

Kawczyk-Krupka A.

autor

Ledwon A.

autor

Karpe J.

autor

Simon-Sieroń M.

autor

Sieroń A.

• Ośrodek Diagnostyki i Terapii Laserowej, Katedra i Klinika Chorób Wewnętrznych, Angiologii i Medycyny Fizykalnej, Śląski Uniwersytet Medyczny

Bibliografia

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