Reversed imidazole nucleosides. Alternative pathway of synthesis

• Autorzy: Walczak K. , Suwiński J.
• Języki publikacji: EN

Abstrakty

EN

The reversed imidazole nucleosides were obtained on three independent routes: a) by the nucleophilic substitution of terminal tosylate group in sugar derivatives with imidazole-1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) salts, b) from monosugar derivatives with unprotected terminal hydroxy group and substituted imidazoles, under the Mitsunobu reactions conditions, c) by the reaction of monosugars possessing terminal primary amino group with 1,4-dinitroimidazoles. Limitation of these routes are discussed.

Słowa kluczowe

EN

reversed nucleosides; imidazoles; DBU; nucleophilic substitution; Mitsunobu reaction

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 1998
• Tom: Vol. 72, nr 6
• Strony: 1028--1036
• Opis fizyczny: Bibliogr. 28 poz., tab.

Twórcy

autor

Walczak K.

autor

Suwiński J.

• Institute of Organic Chemistry and Technology Silesian Technical University Krzywoustego 4 44-100 Gliwice Poland