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Reaction of 5-chloro-6-formylfurocoumarins (3 and 4) withheterocyclic amines and hydrazine derivatives yields corresponding 5-N-substituted and 5-chloro-6-hydrazine derivatives 7a-h and 8a-h, respectively. Bergapten (5,6-c)isoxazole (9) or 6-oxime derivative 10 were obtained by reaction of 3 and 4 with hydroxylamine hydrochloride. Also, reaction of 5-hydroxybergapten (1) and 5-hydroxyisopimpinellin (2) with aliphatic, heterocyclic and aromatic amines beside benzenesulphonamide derivatives affords some novel 5- and 6-substituted aminofurocoumarins 11a-o, 12 a-f, and 13 a-f.The antimiocrobial activity of all compounds was studied.
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Tom
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735--745
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Bibliogr. 15 poz., tab.
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Bibliografia
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bwmeta1.element.baztech-article-BAR2-0001-0057