Synthesis of some new pyrimidines, thienopyrimidines and thiopyranopyrimidines

• Autorzy: Assy M.G. , Amer A.M. , El-Bahaie S. , Halima E.A.
• Języki publikacji: EN

Abstrakty

EN

Isothiocyanate 1 reacted with enaminone 2 to give thioamide 3 that cyclized by sodium hydroxide to pyrimidine 4 but cyclized by bromine to give isothiazole 5, pyrimidine 4 was transformed into thiopyranopyrimidines 7, 9 or 11 upon respective reaction with benzaldehyde, maleic acid , or maleic anhydride. Aminative cyclization of 4 yielded isothiazolopyrimidine 13. Reaction of 4 and ethyl bromoacetate or phenacyl bromides afforded thienopyrimidines 15a-b respectively. Oxidation of 4 yielded oxopyrimidine 16.

Słowa kluczowe

EN

isothiocyanate; pyrimidine; isothiazolopyrimidine; thienopyrimidine

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 1998
• Tom: Vol. 72, nr 1
• Strony: 61--65
• Opis fizyczny: Bibliogr. 13 poz.

Twórcy

autor

Assy M.G.

autor

Amer A.M.

autor

El-Bahaie S.

autor

Halima E.A.