Analogue of Cucurbita maxima trypsin inhibitor III (CMTI-III) with AII L-cysteine residues substituted by L-penicillamine (Pen). Synthesis and evaluation of trypsin inhibitory activity

• Autorzy: Jaśkiewicz A. , Lesner A. , Różycki J. , Kupryszewski G. , Rolka K.
• Języki publikacji: EN

Abstrakty

EN

A 29-peptide, [ Pen(3,10,16,20,22,28) ] CMTI-III, an analogue of Cucurbita maxima trypsin inhibitor from squash seeds was synthesized by the solid phase method using the Fmoc chemistry. The inhibitory activity of the analogue, as measured by the association equilibrium constant (K-a) with bovine beta-trypsin, is of the same order of magnitude as that for the wild CMTI-III.

Słowa kluczowe

EN

polypeptide trypsin inhibitor; analogue of CMTI-III; solid phase peptide synthesis; Fmoc chemistry

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 1998
• Tom: Vol. 72, nr 12
• Strony: 2537--2540
• Opis fizyczny: Bibliogr. 19 poz., tab.

Twórcy

autor

Jaśkiewicz A.

autor

Lesner A.

autor

Różycki J.

autor

Kupryszewski G.

autor

Rolka K.

• Faculty of Chemistry, University of Gdańsk ul. Sobieskiego 18, 80--952 Gdańsk, Poland