2,4-diphenylthiophene induces mainly base pair mutation in Salmonella Typhimurium

• Autorzy: Budzikur K. A. , Mielżyńska-Švach D. , Góra M. , Chachaj A. , Pawłowski M. , Łuczyński M. K.
• Języki publikacji: EN

Abstrakty

EN

Heterocyclic aromatic compounds containing sulfur (S-HET), have been detected in air, soil, marine environment and freshwater sediment. Toxicity and mutagenicity data of this class of substances are scarce. The present study focuses on implications of two aryl thiophenes and their mutagenic properties in Salmonella/microsome test. In our experiment only 2,4-diphenylthiophene showed little mutagenic effect in both variants of activaction (+/-S9) in strain TA100. Thiophene ring joined to K-region of phenanthrene did not change the biological activity of 3,6-dimetoxyphenanthro [9,10-c]thiophene and this compound did not show mutagenic potency.

Słowa kluczowe

EN

Ames test; heterocyclic compounds; mutagenicity; sulfur-PAHs

PL

test Amesa; związki heterocykliczne; mutagenność; siarkowe wielopierścieniowe węglowodory aromatyczne

• Wydawca: University of Warmia and Mazury in Olsztyn, Poland
• Czasopismo: Environmental Biotechnology
• Rocznik: 2012
• Tom: Vol. 8, No. 1
• Strony: 28--31
• Opis fizyczny: Bibliogr. 27 poz., rys.

Twórcy

autor

Budzikur K. A.

autor

Mielżyńska-Švach D.

autor

Góra M.

autor

Chachaj A.

autor

Pawłowski M.

autor

Łuczyński M. K.

• Department of Environmental Biotechnology, University of Warmia and Mazury in Olsztyn, Sloneczna 45G, 10-718 Olsztyn, Poland,

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