Preliminary evaluation of mutagenic activity of two amino derivatives of cyclopenta[c]phenanthrene

• Autorzy: Łuczyński M. K. , Góra M. , Mielżyńska D. , Brzuzan P. , Tejs S. , Pirogowicz P. , Luczynski M.
• Języki publikacji: EN

Abstrakty

EN

The mutagenicity of two, newly synthesized amino-derivatives of cyclopenta[c]phenanthrene (CP[c]Ph) was investigated in the Ames test using TA98 and TA100 histidine dependent Salmonella typhimurium strains. Neither of the examined compounds showed mutagenic activity without metabolic activation. The incorporation of an activation system caused high mutagenicity of CP[c]Ph derivatives in both S. typhimurium strains. The results are compared with the previous data on the mutagenic activity of unsubstituted CP[c]Ph and possible mechanisms of activation are discussed.

Słowa kluczowe

EN

Ames test; phenanthrene; DNA mutations; PAHs

PL

test Amesa; fenantren; mutacje DNA; WWA

• Wydawca: University of Warmia and Mazury in Olsztyn, Poland
• Czasopismo: Environmental Biotechnology
• Rocznik: 2007
• Tom: Vol. 3, No. 1
• Strony: 15--19
• Opis fizyczny: Bibliogr. 21 poz., rys., tab., wykr.

Twórcy

autor

Łuczyński M. K.

autor

Góra M.

autor

Mielżyńska D.

autor

Brzuzan P.

autor

Tejs S.

autor

Pirogowicz P.

autor

Luczynski M.

• Department of Chemistry, University of Warmia and Mazury in Olsztyn, pl. Łódzki 4, 10-957 Olsztyn, Poland.,

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