Oxidative metabolism, mutagenic and carcinogenic properties of some polycyclic aromatic hydrocarbons

• Autorzy: Łuczyński M. K. , Góra M. , Brzuzan P. , Wilamowski J. , Kozik B.
• Języki publikacji: PL

Abstrakty

EN

This attempt to synthesize the present state of knowledge on the correlation between the structure of chosen PAHs and their mutagenic or carcinogenic activity shows that the dependencies cannot be treated univocally. Extreme complexity of the subject, typical for investigations on the boundary between chemistry and biology, inclines one to search for new ways of synthesis of new compounds, which would be of interest for biologists studying the problem of chemical carcinogenesis. On the other hand, there is a strong need for elaborating a standardized test that would explicitly define the carcinogenic properties of a specific compound. The use of a variety of methods for the determination of carcinogenic potency of chemical compounds combined with simultaneous differentiation of structure of examined compounds, sometimes leads to contradictory conclusions. Correlation between mutagenic and carcinogenic activity of some compounds is also sometimes questionable. Modern molecular biology should allow for elaborating a method which would give a satisfactory and reliable answer to the fundamental question: is a specific compound carcinogenous for a human organism? And if so - to what extent?

Słowa kluczowe

PL

metabolizm tlenowy; właściwości mutagenne; właściwości rakotwórcze; wielopierścieniowe węglowodory aromatyczne

EN

oxidative metabolism; mutagenic properties; carcinogenic properties; polycyclic aromatic hydrocarbons

• Wydawca: University of Warmia and Mazury in Olsztyn, Poland
• Czasopismo: Environmental Biotechnology
• Rocznik: 2005
• Tom: Vol. 1, No. 1
• Strony: 16--28
• Opis fizyczny: Bibliogr. 89 poz., rys.

Twórcy

autor

Łuczyński M. K.

• Department of Chemistry, University of Warmia and Mazury in Olsztyn, pl. Łódzki 4, 10-957 Olsztyn

autor

Góra M.

• Department of Organic Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland

autor

Brzuzan P.

• Department of Environmental Biotechnology, Faculty of Environmental Sciences and Fisheries, University of Warmia and Mazury in Olsztyn, Słoneczna 45G, 10-709 Olsztyn, Poland

autor

Wilamowski J.

• Department of Organic Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland

autor

Kozik B.

• Department of Organic Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland

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