Evaluation of cytocompatibility of PLGA and PGLA-based nanocomposite biomaterials in osteoblast cultures

• Autorzy: Ścisłowska-Czarnecka A. , Stodolak-Zych E. , Prawdzik E. , Boguń M. , Menaszek E.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to evaluate biocompatibility of multilevel composites based on bioresorbable poly(lactide-co-glycolide) (PGLA). Polymer matrix was modified with multidimensional (MD) short biopolymer fibers of calcium alginate (CA) containing bioactive ceramic nanoparticles (nanohydroxyapatite - HA or nanosilica - SiO2). The nanocomposite fibres present in the polymer samples influenced cells morphology, viability and secretory activity which was estimated using human osteoblasts cells (NHOst). The results indicate that biodegradable nanocomposite CA-HA/PGLA improves biological properties of the basic biomaterial (PGLA) suggesting its potential application for bone tissue engineering.

Słowa kluczowe

EN

cells materials interaction; cells factors; composites; nanocomposites

PL

kompozyty; nanokompozyty

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2012
• Tom: Vol. 15, no. 112
• Strony: 2--5
• Opis fizyczny: Bibliogr. 18 poz., rys., wykr.

Twórcy

autor

Ścisłowska-Czarnecka A.

• University School of Physical Education, Faculty of Rehabilitation, Physiotherapy Department, al. Jana Pawła II 78, 31-571 Kraków, Poland

autor

Stodolak-Zych E.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, Al. A. Mickiewicza 30, 30-059 Krakow, Poland

autor

Prawdzik E.

• Jagiellonian University, Collegium Medicum, Department of Cytobiology, ul. Medyczna 9, 30-688 Krakow, Poland

autor

Boguń M.

• Technical University of Lodz, Faculty of Material Technologies and Textile Design, Department of Man-Made Fibres, ul. Żeromskiego 116, 50-952 Lodz , Poland

autor

Menaszek E.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, Al. A. Mickiewicza 30, 30-059 Krakow, Poland
• Jagiellonian University, Collegium Medicum, Department of Cytobiology, ul. Medyczna 9, 30-688 Krakow, Poland

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