Vascular endothelial cells in cultures on metal/C:H composite films

• Autorzy: Bacakova L. , Noskova L. , Koshelyev H. , Biederman H.
• Języki publikacji: EN

Abstrakty

EN

Adhesion, proliferation and maturation of vascular endothelial cells in cultures derived from the bovine pulmonary artery (line CPAE) were studied on Ti/C:H or Ag/C:H films prepared on glass using dc magnetron plasma deposition. The concentration of Ti or AG in the films ranged from 0% to 20%. On Ag/C:H layers, increasing concentration of silver markedly decreased cell viability. Only samples with very low silver content allowed cell spreading and formation of continuous endothelial layer. Although long-term presence of this material in patient's organism would not be advantageous, antimicrobial effect of silver may be favorable for short term applications, e.g. coating of catheters. On Ti/C:H layers, the cells were similarly or more active in adhesion, proliferation and maturation than those on glass or pure amorphous carbon, respectively. This material could be suitable for long-term use in both soft and hard tissue surgery, e.g. for inner coating of vascular prostheses or surface modification of artificial bone implants.

Słowa kluczowe

EN

composites; vascular biomaterials

PL

kompozyty

• Wydawca: Polskie Stowarzyszenie Biomateriałów
• Czasopismo: Inżynieria Biomateriałów
• Rocznik: 2004
• Tom: R. 7, nr 37
• Strony: 18--20
• Opis fizyczny: Bibliogr. 12 poz., rys., wykr.

Twórcy

autor

Bacakova L.

• Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic

autor

Noskova L.

• Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic

autor

Koshelyev H.

• Department of Physics, Faculty of Electrical Endineering, Czech Technical University in Paruge, Technicka 2, Prague, 6, Czech Republic

autor

Biederman H.

• Department of Macromolecular Physics, Faculty of Mathematics and Physics, Chrles University, v Holesovickach 2, Prague 8, czech Republic

Bibliografia

• [1] Fisher J., Hu X.Q., Tipper J.L., Stewart T.D., Williams S., Stone M.H., Davies C., Hatto P., Bolton J., Riley M., Hardaker C., Isaac G.H., Berry G., Ingham E.: Proc. Inst. Mech. Eng., [H] 216: 219-203,2002.
• [2] Yamazaki K., Litwak P., Tagusari O., Mori T., Kono K., Kameneva M., Watach M., Gordon L., Miyagishima M., Tomioka J., Umezu M., Outa E., Antaki J.F., Kormos R.L., Koyanagi H., Griffith B.P.: Artif. Organs., 22: 466-474, 1998.
• [3] Jones M.I., McColl I.R., Grant D.M., Parker K.G., Parker T.L.: J.Biomed. Mater. Res., 52:413-421, 2000.
• [4] Schaub R.D., Kameneva M.V., Borovetz H.S., Wagner W.R.: J.Biomed. Mater. Res., 49:460-468, 2000.
• [5] Krishnan L.K., Varghese N., Muraleedharan C.V., Bhuvaneshwar G.S., Derangere F., Sampeur Y., Suryanarayanan R.: Biomol Eng 19: 251-253, 2002.
• [6] Schroeder A., Francz G., Bruinink A., Hauert R., Mayer J., Wintermantel E.: Biomaterials, 21: 449-456, 2000.
• [7] Bacakova L, Stary V, Kofronova O, Lisa V: J.Biomed Mater Res 54: 567-578, 2001.
• [8] Trautner B.W., Darouiche R.O.: Arch. Intern. Med., 164: 842-850, 2004.
• [9] Samuel U., Guggenbichler J.P.: Int. J. Antimicrob. Agents., 2004 23 Suppl 1: S75-S758, 2004.
• [10] Boldyryeva H., Hlidek P., Biederman H., Slavinska D., Choukourov A.: Thin Solid Films 442: 86-92, 2003.
• [11] Bacakova L., Lisa V., Kubinova L., Wilhelm J., Novotna J., Eckhart A., Herget J.: Virchow's Archiv, 440: 50-62,2002.
• [12] Sato H., Tsuji H., Ikeda S., Ikemoto N., Ishikawa J., Nishimoto S.: J.Biomed. Mater. Res., 44: 22-30, 1999.