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Degradable scaffold materials for cartilage regeneration

Treść / Zawartość
Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Two scaffolding materials for cartilage regeneration were produced from poly(L-lactide-co-glycolide) (PLG) and PLG modified with sodium hyaluronate (PLG-Hyal). The scaffolds were characterized in terms of their microstructure and surface chemistry. Biological properties of the scaffolds were also evaluated by implantation of the scaffolds into auricular cartilage of the rabbits for 1 and 4 weeks. Histological and histochemical examinations show that both scaffolds promote regeneration of the cartilage, although the quickest regeneration was found after implementation of PLG-Hyal.
Słowa kluczowe
Rocznik
Strony
3--5
Opis fizyczny
Bibliogr. 9 poz., rys., wykr.
Twórcy
autor
  • AGH-UST, Department of Biomaterials, 30, Mickiewicza Al., 30-059 Cracow, Poland
autor
  • Silesian Medical University, Department of Otolaryngology, 10, M. Curie-Skłodowskiej str., 41-800 Zabrze, Poland
autor
  • Jagiellonian University, Collegium Medicum, Faculty of Pharmacy, Department of Cytobiology and Histochemistry, 9, Medycznas tr., 30-688 Cracow, Poland
Bibliografia
  • [1] Ciorba A., Martini A., Tissue engineering and cartilage regeneration for auricular reconstruction, Int. J. Pediatric Otorinolaryngology 2006; 70: 1507-1515.
  • [2] Romo T., Fozao M., Sclafani A.; Microtia reconstruction using a porous polyethylene framework, Facial Plast. Surg. 2000; 126: 538- 547.
  • [3] Vunjak-Novakovic G., Martin I., Obradovic B., Treppo S., Grodzinsky A.J., Langer R., Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage, J. Orthop. Res. 1999; 17(1): 130-8.
  • [4] Lee C.-T., Lea Y.-D., Preparation of porous biodegradable poly(lactide-co-glycolide)/hyaluronic acid blend scaffolds: Characterization, in vitro cells culture and degradation behaviors. J. Mater. Sci.: Mater. Med. 2006; 17: 1411-1420.
  • [5] Dobrzyński P., Kasperczyk J., Janeczek H., Bero M., Synthesis of biodegradable copolymers with the use of low toxic zirconium compounds. 1. Copolymerization of glycolide with L-lactide initiated by Zr{Acac)4. Macromolecules 2001; 34: 5090-5103.
  • [6] Goldberg AF, Barka T. Acid phosphatase activity in human blood cells, Nature 1962; 195: 297.
  • [7] Pamuła E., Błażewicz M., Paluszkiewicz C., Dobrzyński P., FTIR study of degradation products of aliphatic polyesters-carbon fibres composites, J. Mol. Struct. 2001; 596: 69-75.
  • [8] Wang W., A novel hydrogel crosslinked hyaluronan with glycol chitosan, J. Mater. Sci.: Mater. Med. 2006; 17: 1259-1265.
  • [9] Schwach G., Vert M., In vitro and in vivo degradation of lactic acid- based interference screws used in cruciate ligament reconstruction. Int. J. Biol. Macromol. 1999; 25: 283-291.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-AGH5-0014-0086
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