Zgodność strukturalno-adaptacyjna połączeń kości z porowatymi implantami na podstawie tradycyjnego jednofazowego i współczesnego dwufazowego porosprężystego modelu biomechanicznego tkanki kostnej

• Autorzy: Uklejewski R. , Winiecki M. , Rogala P.

Warianty tytułu

EN

On the structural-adaptive compatibility of bone with porous coated implants on the base of the traditional one-phase and the modern two-phase poroelastic biomechanical model of bone tissue

• Języki publikacji: PL

Abstrakty

PL

Biomechaniczną konstrukcję układu kość-implant, np.: konstrukcję sztucznego stawu biodrowego charakteryzuje zespół cech materiałowych, geometrycznych i dynamicznych, dobranych ze względu na zamierzony rekonstrukcyjny cel endoprotezoplastyki. Zagadnienie zgodności strukturalno-biomechanicznej pomiędzy porowatym implantem a kością należy do kluczowych ze względu na spełnianą w szkielecie rolę. W tym zagadnieniu należy w pierwszym rzędzie wyodrębnić problem zgodności strukturalno-adaptacyjnej implantów ortopedycznych pokrytych porowatą warstwą wierzchnią (porous coated implants) z porowatą tkanką kostną. Właściwości strukturalno-osteoindukcyjne porowatych materiałów współpracujących z tkanką kostną warunkują adaptacyjne wrastanie tej tkanki do przestrzeni porowej warstw wierzchnich implantów, co z kolei determinuje właściwe i trwałe umocowanie implantu w kości. Praca zawiera krytyczny przegląd opublikowanych dotąd ważniejszych prac badawczych dotyczących istotnego z punktu widzenia inżynierii biomateriałów stosowanych w układzie kostno-stawowym człowieka zagadnienia zgodności strukturalno-adaptacyjnej połączenia kość-implant. Wykazano, że zagadnienie to nie może być w sposób należyty rozwiązane na podstawie tradycyjnego jednofazowego modelu biomechanicznego tkanki kostnej, a w literaturze przedmiotu brak jest jednoznacznych wytycznych dotyczących identyfikacji istotnych parametrów mikrostruktury porowatych pokryć implantów otopedycznych. Zdaniem autorów, współczesny dwufazowy porosprężysty model biomechaniczny tkanki kostnej stwarza w tym względzie nowe możliwości, które pozwolą na zidentyfikowanie istotnych parametrów porostruktury, warunkujących strukturalno-osteoindukcyjne właściwości porowatych warstw wierzchnich implantów ortopedycznych

EN

The biomechanical construction of an orthopaedic implant, e.g. construction of artificial hip joint, is characterized by a set of material, geometrical and dynamic properties, designed to fulfill the joint reconstruction arthroplasty requirements. The problem of structural-biomechanical compatibility between porous implant and bone is a key-question in respect to the role performed in skeleton. At the first, in this matter, the problem of structural-adaptive compatibility of orthopaedic implants porous coatings with porous bone tissue should be stated. The structural-osteoinductive properties of biomaterial influence the adaptive ingrowth of bone tissue into the pore space of a porous coating , which in turn determines the proper and permanent fixation of the implant in its bony surroundings. This paper presents a critical review of the published most significant research works dealing with the problem of the structural-adaptive compatibility of bone-implant fixation, important from the biomaterials engineering view point. There is shown that the problem cannot be appropriately analysed and solved on the base of the traditional one-phase biomechanical model of bone tissue and that it is still lack of clearly defined parameters of microstructure for porous coatings on the bone implants. In the authors opinion, the modern two-phase poroelastic biomechanical model of bone tissue gives new possibilities for the identification of the significant parameters influencing the structural-osteoinductive properties of porous coatings of othopaedic implants

Słowa kluczowe

PL

implanty; tkanka kostna; model biomechaniczny

EN

implants; bone tissue; biomechanical model

• Wydawca: Polskie Stowarzyszenie Biomateriałów
• Czasopismo: Inżynieria Biomateriałów
• Rocznik: 2006
• Tom: R. 9, nr 54-55
• Strony: 1--13
• Opis fizyczny: Bibliogr. 116 poz., rys., tab.; pol.-ang

Twórcy

autor

Uklejewski R.

• Zakład Podstaw Bioinżynierii Medycznej i Elektrotechniki, Instytut Techniki, Akademia Bydgoska im. Kazimierza Wielkiego w Bydgoszczy

autor

Winiecki M.

• Katedra Podstaw Konstrukcji Maszyn, Politechnika Poznańska

autor

Rogala P.

• Klinika Ortopedii Akademii Medycznej im. Karola Marcinkowskiego w Poznaniu, Ortopedyczno-Rehabilitacyjny Szpital Kliniczny w Poznaniu Im. W. Degi w Poznaniu

Bibliografia

• [1] Albrektsson. T., Carlsson, L.V., Morberg, P., et al.: Directly Bone- Anchored Implants, In: Bone Implant Interface, Hurley, R., (Ed.), Mosby, St Luis, 1994, 97-120.
• [2] Aoki, H.: Medical Applications of Hydroxyapatite, Ishiyaku Euroamerica, Inc., Tokyo-St. Louis, 1994.
• [3] Barrack, R.L., Cook, S.D., Patrom, LP.: Induction of Bone Ingrowth From an Acetabular Defect to a Porous Surface with Osteogenic Protein-1, Clin. Orthop.; 2003; 417:41-9.
• [4] Ben-Nissan, B., Cai, C.S., Gross, K.A.: Effect of Solution Aging on Sol-Gel Hydroxyapatite Coatings; Bioceramics. 10 1997, 175- 78.
• [5] Berry, J.L., Geiger, J.M., Moran, J.M.. Skraba, J.S., Greenwald. A.S.: Use of Tricalcium Phosphate or Electrical Stimulation to Enhance the Bone-Porous Implant Interface. J. Biomech. Mater. Res., 1986: 20: 65-77.
• [6] Będziński, R.. Bernakiewicz, M., Ścigała, K.: Biomechanical Aspects of Artificial Joint Implantation in Lower Limb, Journal Of Theoretical And Applied Mechanics, 3; 37, 1997, 455-479.
• [7] Będziński, R.: Biomechanika Inżynierska. Zagadnienia Wybrane, Oficyna Wyd. Politechniki Wrocławskiej, Wrocław 1997.
• [8] Biernbaum, B.E., Nairus, J., Kuesis, D., Morrison, J.C., Ward, D.: Ceramic-On-Ceramic Bearings In Total Hip Arthroplasty., Clin. Orthop., 2002; 405, 158-63.
• [9] Bigliani, L.U., Flatow, E.L.: Shoulder Arthroplasty, Springer, 2005.
• [10] Blencke, B.A., Bromer, H., Deutcher, K.K.: Compatibility and Long-Term Stability Of Glass Ceramic Implants, J. Bioed. Mater. Res., 1978. 12. 307-316.
• [11] Błażewicz, S., (Ed.), Stoch, L., (Ed.): Problemy Biocybernetyki i Inżynierii Biomedycznej, Tom 4, Biomateriały, Akademicka Oficyna Wydawnicza Exit. Warszawa 2003.
• [12] Bobyn, J.D., Hacking, S.A., Krygier, J.J., Harvey, E.J., Little, D.G., Tanzer, M.: Zoledronic Acid Causes Enhancement Of Bone Growth Into Porous Implants, J. Bone Joint Surg. 2005; 87-B: 416 -420.
• [13] Bobyn, J.D., Tok, K-K., Hacking, S.A.. Tanzer, M., Krygier, J.J.: The Tissue Response to Porous Tantalum Acetabular Cups: A Canine Model, J. Arthroplasty. 1999;14: 347-54.
• [14] Bobyn, J.D., Pillar; R.M.. Cameron, H.U., Weatherly, G.C.: The Optimum Pore Size For The Fixation Of Porous-Surfaced Metal Implants By The Ingrowth Of Bone. Clin. Orthop., 1980; 150: 263- 270.
• [15] Brighton, C.T., Wang, W.; Seldes, R., Zhang, G., Pollack S.R.: Signal Transduction in Electrically Stimulated Bone Cells, J. Bone Jt. Surg., 2001; 83A, 1514-1523.
• [16] Brooker, A.F., Collier, J.P.: Evidence Of Bone Ingrowth Into A Porous-Coated Prosthesis, J. Bone Joint Surg., 1984; 66a: 619-621.
• [17] Buch, F., Albrektsson, T., Herbst, E.: Direct Current Influence on Bone Formation In Titanium Implants, Biomaterials, 1984, 3, 341.
• [18] Bugbee, W.D., Engh, C.A.: Cementless Femoral Component: Extensively Coated, In: Callaghan J.J., Rosenberg A.G., (Ed), Rubash H.E., (Ed): The Adult Hip, Lippincott-Raven Publishers, Philadelphia, New York, 1998, 1023-1040.
• [19] Callaghan, J.J., (Ed.). Rosenberg, A.G., (Ed.), Rubash, H.E., (Ed.): The Adult Hip, Lippincott-Raven Publishers, Philadelphia, New York, 1998.
• [20] Callaghan, J.J.: The Clinical Results and Basic Science Of Total Hip Arthroplasty With Porous Coated Prostheses, J. Bone Joint Surg., 1993; 75A; 299-312.
• [21] Cameron, H.U.: Smooth Metal-Bone Interface, In: Hurley, R., (Ed.) Bone Implant Interface, Mosby, St Luis, 1994, 121-144.
• [22] Cameron, H.U.: The Implant Bone Interface: Porous Metals, In: Hurley, R., (Ed.), Bone Implant Interface, Mosby. St Luis, 1994, 145-168.
• [23] Celeste, A.J., Iannazzi, J.A.. Taylor, R.C., Hewick, R.M., Rosen; V., Wang, E.A., Wozney, J.M.: Identification Of Transforming Growth Factor Beta Family Members Present In Bone-Inductive Protein Purified From Bovine Bone, Proc. Natl. Acad. Sci. USA 1990; 87: 9843-7.
• [24] Charnley, J.: Low Friction Arthroplasty Of The Hip, Springer- Verlag, Berlin, 1979.
• [25] Charnley, J.: Acrylic Cement in Orthopaedic Surgery, Churchill Livingstone, Edinburgh, 1970.
• [26] Chern Lin, J.H., Liu, M.L., Ju, C.P.: Structure And Properties Of Hydroxyapatite-Bioactive Glass Composites Plasma Sprayed On Ti6Al4V, Journal Of Material Science: Materials In Medicine. 5. 1994, 279-283.
• [27] Clemow, A.J.T., Wienstein, A.M., Klawitter, J.J.. Koeneman, J., Anderson, J.: Interface Mechanics of Porous Titanium Implants, J. Biomed. Mater. Res., 1981, 15, 73-82.
• [28] Cook, S.D.; Salkeld, S.L., Patron, L.P., Barrack, R.L.: The Effect Of Demineralized Bone Matrix Gel On Bone Ingrowth And Fixation Of Porous Implants, J. Arthroplasty, 2002; 17: 402-8.
• [29] Cook, S.D., Thomas, K.A.. Kay, J.F., Jarcho, M.: Hydroxyapatite-Coated Porous Titanium For Use As An Orthopedic Biologic Attachment System, Clin. Orthop., 1988; 230: 303-12.
• [30] Cowin, S.C.: Bone Poroelasticity, In: Cowin, S.C., (Ed.): Bone Biomechanics Handbook, 2. Ed., Crc Press, Boca Raton; FI USA, 2001.
• [31] Currey, J.D.: Bones: Structure And Mechanics, Princetown University Press. Princeton and Oxford, 2002.
• [32] Dai; K.R., Liu, Y.K.. Park, J.B.. Zhang, Z.K.: Bone Particle Impregnated Bone Cement: An In Vivo Weight-Bearing Study, J. Biomed. Mater. Res.; 1991, 25, 141-156.
• [33] D'Antonio, J.A., Capello, W.N., Manley, M.T., Bierbaum, B.: New Experience with Alumina-On-Alumina Ceramic Bearings for Total Hip Arthroplasty, J. Arthroplasty, 2002; 17: 390-7.
• [34] D'Antonio, J.A., Capello, W.N., Manley, M.T., Geesink; R.: Hydroxyapatite Femoral Stems For Total Hip Arthroplasty: 10 to 13 Year Fallow Up, Clin. Ortop., 2001; 393: 101-11.
• [35] de Groot K.: Bioceramics Of Calcium Phosphate, Crc Press, Boca Raton, FI., 1983.
• [36] Ducheyne, P., Van Raemdonck, W., Heughebaert, J.C., Heughebaert; M.: Structural Analysis of Hydroxyapatite Coatings on Titanium, Biomaterials, 7(2), 1986, 97-103.
• [37] Engh, C.A.. Claus, A.M., Hopper, R.H.: Long-term Results Using the Anatomic Medullary Locking Hip Prosthesis, Clin. Orthop., 2001; 393: 137-46.
• [38] Enqh, C.A., Massin, P. Suthers, K.: Roentgenographic Assessment of the Biologic Fixation of Porous-Surface Femoral Components, Clin. Orthop., 1992; 284: 310-2.
• [39] Engh, C.A., Glassman; A.H., Suthers, K.E.: The Case for Porous-Coated Hip Implants, Clin. Orthop., 1990, T. 261, 63-81.
• [40] Green, J.R., Muller, K., Jaeggi, K.A.: Preclinical Pharmacology of CGP42'446, A New Potent, Heterocyclic Bisphosphonate Compound., J. Bone Miner. Res., 1994: 9: 745-751.
• [41] Grote, J.J.: Reconstruction of the Middle-Ear with Hydroxyapatite Implants: Long Term Results, Ann. Otol. Rinol. Laryngol., 144, 12, 1990.
• [42] Gunzburg, R., (Ed.), Mayer, H.M., (Ed.), Szpalski, M., (Ed.), Aebi. M., (Ed.): Arthroplasty of the Spine, European Spine Journal, Vol. 11, Suppl. 2, Springer; 2004.
• [43] Harris, W.H.: Hybrid Total Hip Replacement, Clin. Orthop., 1996, T. 333, 155-164.
• [44] Hart, R.T., Davy, D.T. Heigle, K.G.: Mathematical Modelling Of Stress Adaptation Process in Bone, Calcif. Tiss. Int, 1984; 36, Suppl. 1, 104-109.
• [45] Hench, L.L., Paschall, H.A.: Direct Chemical Bond of Bioactive Glass-Ceramic Materials To Bone And Muscle, J. Biomed. Mater. Res. Symp. No. 4, 1973, 25-43.
• [46] Hench, L.L.: Bioactive Glasses, Ceramics and Composites, In: Hurley R. (Ed.), Bone Implant Interface; Mosby, St Luis, 1994, 181-190.
• [47] Henrich, D.E., Cram, A.E., Park, J.B., Liu, Y.K., Reddi, H.: Inorganic Bone and Bone Morphogenic Protein Impregnated Bone Cement: A Preliminary In Vivo Study, J. Biomed. Mater. Res. 1993, 27, 227-280.
• [48] Herman, H.: Plasma-Sprayed Coatings. Scien. Am., 1988, 259: 78-88.
• [49] Hintermann, B.: Total Ankle Arthroplasty, Springer, Wien, New York, 2004.
• [50] Hirshhorn, J.S., Mcbeath, A.A., Dustoor, M.R.: Porous Titanium Surgical Implant Materials; J. Biomed. Mater. Res. Symp., No. 2; 1972, 49-69.
• [51] Hirshhorn, J.S., Reynolds, J.T.: Powder Metallurgy Fabrication of Cobalt Alloy Surgical Implant Materials, In: Korostoff, E., (Ed.): Research in Dental and Medical Materials, Plenum Press, New York, 1969.
• [52] Homsy, C.A., Cain, T.E., Kessler, F.B., Anderson, M.S., King, J.W.: Porous Implant Systems for Prosthetic Stabilization, Clin. Orthop. Rel. Res., 1972, 89, 220-231.
• [53] Jasty, M., Rubash, H.E., Palement, G.D., Bragdon, C.R., Parr, J., Harris, W.H.: Porous Coated Uncemented Components in Experimental Total Hip Arthroplasty in Dogs. Effect of Plasma-Sprayed Calcium Phosphate Coatings on Bone In-Growth, Clin. Orthop., 1992; 280: 300-9.
• [54] Jee; W.S.S.: Integrated Bone Tissue Physiology: Anatomy and Physiology, In: Cowin, S.C., (Ed.): Bone Biomechanics Handbook, 2. Ed., Crc Press; Boca Raton, FI USA, 2001.
• [55] Kay, J.F.: Bioactive Surface Coatings; Cause for Encouragement and Caution, J. Oral Implant, 1988; 16, 43-54.
• [56] Kienapfel, H.; Summer, D.R., Turner, T.M., Urban, R.M., Galante, J.O.: Efficacy of Autograft and Freeze-Dried Allograft to Enhance Fixation of Porous Coated Implants in The Presence of Interface Gaps, J. Orthop. Res., 1992; 10: 423-33.
• [57] Klawitter, J.J., Hulbert. S.F.: Application of Porous Ceramics for the Attachment of Load Bearing Internal Orthopaedic Application, Biomed. Mater. Res. Symp., No. 2, 1972; 161-229.
• [58] Kozinn, S.C., Hedley, A.K., Urist, M.R.: Augmentation Of Bone Ingrowth: I. Ingrowth Into Bone Morphogenic Protein (BMP) Impregnated Porous Implants, In: Transactions, 28th Annual Meeting, Orthopaedic Research Society 1982, 7, 181.
• [59] Kusz, D.: Rys historyczny i uwarunkowania endoprotezoplastyki stawu biodrowego, Inżynieria Materiałowa, 2 1998. 36-39.
• [60] Kusz, D.: Biomechaniczne aspekty endoprotezyk stawu biodrowego, Inżynieria Materiałowa, Nr 2/1997, 39-44.
• [61 ] Lewis, G.: The Elbow Joint and Its Total Arthroplasty, Bio-Med. Mater. Eng., 6, 353, 1996.
• [62] Liu, Y.K., Njus, G.O., Park, J.B., Stienstra, D.: Bone Particle Impregnated Bone Cement, I. In Vitro Study, J. Biomed. Mater. Res., 1987, 21, 247-261.
• [63] Lord, G.A., Hardy, J.R., Kummer, F.J.: An Uncemented Total Hip Replacement, Clin. Qrthop., 1979, T. 141, 2-16.
• [64] Marciniak, J.: Biomateriały, Wydawnictwo Politechniki Śląskiej, Gliwice 2002.
• [65] McKoy, B.E., An, Y.H., Friedman, R.J.: Factors Affecting The Strength Of The Bone-Implant Interface, In: An, Y.H., (Ed.), Draughn, R.A., (Ed.): Mechanical Testing Of Bone And The Bone-Implant Interface, CRC Press, Boca Raton, London, New York Washington Dc, 2000.
• [66] Meuli, H.C.: Total Wrist Arthroplasty, Experience with Noncemented Prosthesis, Clin. Orthop., 342, 77, 1997.
• [67] Misch, C.E.: Dental Implant Prosthetics, Mosby-Year Book, 2004.
• [68] Mittlemeier, H.: Anchoring Hip Endoprosthesis Without Bone Cement, In: Schaldach; M., (Ed.), Hohmann, D., (Ed.): Advances In Artificial Hip And Knee Joint Technology, Springer-Verlag. Berlin; 1976, 387-402.
• [69] Moore, A.T.: The Self-Locking Metal Hip Prosthesis, J. Bone Joint Surg. Am., 1957, T. 39 - A(4), 811-827.
• [70] Mow, V.C., (Ed.), Hayes, W.C., (Ed.): Basic Orthopedic Biomechanics, Lippincott Williams & Wilkins, New York 1997.
• [71] Niesz, D.E.; Tennery, V.J.: Ceramics for Prosthetic Application - Orthopedic, Dental and Cardiovascular, Mat. And Ceram. Inform. Center., MCIC - 74 - 21. 1974.
• [72] Niles, J.L., Lapitsky, M.: Biomechanical Investigation of Bone- Porous Carbon and Metal Interfaces, Biomed. Mater. Res. Symp., 1975, 4, 63-84.
• [73] Ong, J.L., Lucas, L.C., Lacefield, W.R., Rigney, E.D.: Structure, Solubility and Bond Strength of Thin Calcium Phosphate Coatings Produced By Beam Sputter Deposition, Biomaterials 13 (4), 1992, 249-254.
• [74] Ostrowski, K., (Ed.): Histologia, PZWL; 1998.
• [75] Overgaard, S.: Calcium Phosphate Coatings For Fixation Of Bone Implants, Acta Orthopaedica Scandinavica, Suppl., No. 297, Vol. 71, 2000.
• [76] Park, J.B., Choi, W.W., Liu; Y.K., Haugen, T.W.: Bone Particle Impregnated Polymethylmethacrylate: In Vitro And In Vivo Study. In: Van Steenberge, D., (Ed.): Tissue Integration in Oral And Facial Reconstruction, Excerpta Medica, Amsterdam, 1986, 118-124.
• [77] Park, J.B., Kenner, G.H.: Effect of Electrical Stimulation on the Tensile Strength of the Porous Implant and Bone Interface, Biomater. Med. Dev. Artif. Org., 1975, 3, 233-243.
• [78] Park, J.B., Bronzino, J.D.: Biomaterials: Principles And Applications, Boca Raton, London, New York, Washington, D.C., CRC Press 2003.
• [79] Park, J.B.: Orthopedic Prosthesis Fixation, In: Bronzino, J.D., (Ed.): Biomedical Engineering Handbook, Boca Raton, CRC Press, 1995, 704-723.
• [80] Parthofer, R., Weinhart, R., Frehner; W.: 15 Years of Personal Experience with Cement-Free Primary Hip-Joint Endoprostheses, Chir. Narz. Ruchu Orthop. Pol., 1994, T. 59 (Suppl. 3), 218-222.
• [81] Popoviol, A.F.: Polyvinyl Plastic Sponge In Experimental Orthopaedic Surgery: A Preliminary Report, Bull Georgetown Univ. Med. Cent., 7- 177.
• [82] Predecki, P., Stephan, J.E., Auslander, B.E.; Mooney, V.L., Kirkland, K.: Kinetic of Bone Growth Into Cylindrical Channels in Aluminium Oxide and Titanium, J. Biomed. Mater. Res., 1972, 6, 375-400.
• [83] Prendergast, P.J.: Bone Prostheses and Implants, In: Cowin, S.C.; (Ed.): Bone Biomechanics Handbook, 2. Ed., CRC Press, Boca Raton; FI USA, 2001.
• [84] Rivero, D.P., Landon. G.C., Skipor, A.K., Urban, R.M., Galante, J.O.: Effect of Pulsing Electromagnetic Fields on Bone Ingrowth in a Porous Material (Abstract), Trans. Orthop. Res. Soc., 1986; 11: 492.
• [85] Robertson, D.M., Pierre, L., Chehal, F.: Preliminary Observations of Bone Ingrowth into Porous Material, J. Biomed. Mater. Res., 10, 335, 1976.
• [86] Rogala P.: Patent europejski nr 072418 B1, pt.: “Endoprothesis” udzielony przez European Patent Office w 1999 r. oraz patent amerykański nr 5.91,759, pt.: “Acetabulum Endoprothesis And Head” udzielony w ramach porozumienia PCT, patent kanadyjski nr 2,200,064, pt.: “Method And Endoprothesis To Apply This Implantation” udzielony w ramach PCT.
• [87] Rogala, P., Uklejewski, R.; Stryła, W.: Współczesny porosprężysty model biomechaniczny tkanki kostnej. Część 1 i 2, Chir. Narz. Ruchu Orthop. Pol., 2002; Nr 67 (3), 309-316: 64 (4), 395-403.
• [88] Rogala, P., Uklejewski. R.: New Model and Biomechanical Concept of Total Hip Arthroplasty; In: Proceedings of The International Conference “Bone 2003”, Maastricht (NI) 9-11. Oct. 2003.
• [89] Russotti, G.M., Okada, Y., Fitzgerald, R.H. Jr, Chao; E.Y.S., Gorski, J.P.: Efficacy of Using a Bone Graft Substitute to Enhance Biological Fixation of a Porous Metal Femoral Component, In: Brand R.A., (Ed.): The Hip. Proc. of 15th Open Science Meeting Of Hip Society, St. Louis Mosby 1987:120-54.
• [90] Sauer, B.W. Weinstein, A.M., Klawitter, J.J., Hulbert, S.F., Leonard, R.B., Bagwell, J.G.: The Role of Porous Polymeric Materials in Prosthesis Attachment, J. Biomed. Mater. Res. Symp., No. 5; 1974, 5, 145-156.
• [91] Sculco. T.P., (Ed.). Martucci, E.A., (Ed.): Knee Arthroplasty, Springer, 2002.
• [92] Shimizu; T., Zerwekh, J.E., Videman, T., et al.: Bone Ingrowth into Porous Calcium Phosphate: Influence of Pulsing Electromagnetic Field, J. Orthop. Res., 1988, 6, 248.
• [93] Silva, M., Lee, K.H.. Heisel, C., Dela Rosa, M.A., Schmalziried, T.P.: The Biomechanical Results of Total Hip Resurfacing Arthroplasty, J. Bone Joint Surg. Am., 2004; 86a: 40-46.
• [94] Simmen, B.R.; (Ed.), Allieu, Y., (Ed.), Lluch, A., (Ed.), Stanley, J., (Ed.): Hand Arthroplasties, Taylor & Francis Group, 2000
• [95] Sivash K.M.: The Development of a Total Metal Prosthesis for the Hip Joint from a Partial Joint Replacement, Reconstr. Surg. Traumat.. 1969, T. 11, 53-62.
• [96] Smith, L.: Ceramic-Plastic Material as a Bone Substitute, Arch. Surg., 1963, 87, 653-661.
• [97] Soballe, K., Hansen, E.S., Brockstedt-Rasmussen, H., Hjortdal, V.E., Juhl, G.I., Padersen, C.M., Hvid, I., Bunger, C.: Fixation of Titanium- And Hydroxyapatite Coated Implants in Arthritic Osteonic Bone, J. Arthroplasty, 1991, 6(4), 307-316.
• [98] Soballe, K., Hansen, E.S., Brockstedt-Rasmussen, H.; Pedersen, C.M., Bunger; C.: Bone Graft Incorporation Around Titanium- Alloy And Hydroxyapatite-Coated Implants in Dogs, Clin. Orthop., 1992; 274; 282-93.
• [99] Soballe, K.: Hydroxyapatite Ceramic Coating for Bone Implant Fixation, Acta Orthopaedica Scandinavica. Suppl.. 255, 64, 1993.
• [100] Stryła, W., Uklejewski, R., Rogala, P.: Modern two-phase biomechano-electrophysiological model of bone tissue. Implications for rehabilitation research and practice, 8th Congress of European Federation for Research in Rehabilitation, Ljubliana, Slovenia, 13- 17 June 2004; extended summary in: Int. Journal of Rehabilitation Research, 2004, Vol. 27 Suppl. 1, 175-177.
• [101] Tanzer, M., Harvey, E., Kay, A., Morton, P., Bobyn, J.D.: Effect of Noninvasive Low Intensity Ultrasound On Bone Growth Into Porous-Coated Implants. J. Orthop. Res., 1996; 14: 901-906.
• [102] Teloken, M.A., Bissett, G.; Hozack, W.J., Sharkey, P.F., Rothman, R. H.: Ten To Fifteen Year Follow-Up After Total Hip Arthroplasty With a Tapered Cobalt-Chromium Femoral Component (Tri- Lock) Inserted Without Cement., J. Bone Joint Surg. (Am.), 2002; 84-A: 2140-4.
• [103] Trancik, T., Vinson, N.: The Effect Of Prostaglandin F2, Alpha On Bone Ingrowth Into A Porous-Coated Implant (Abstract)., Trans. Othop. Res. Soc., 1990; 15: 167.
• [104] Turner, T.M., Sumner, D.R.. Urban, R.M., Riviero, D.P., Galante, J.O.: A Comparative Study of Porous Coatings in a Weight- Bearing Total Hip Arthroplasty Model: J. Bone Joint Surg. Am.; 1986, 68, 1396-1409.
• [105] Uklejewski, R.: Living Bone As Biomechatronic System, Machine Dynamics Problems, Vol. 28, No 4, 2004, 165-169.
• [106] Uklejewski, R.: O efektach elektromechanicznych w porowatej kości zbitej wypełnionej płynem fizjologicznym i efekcie akustoelektrycznym w trzonach kości długich mokrych, /rozprawa habilitacyjna/, Wydawnictwo Inst. Biocybern. i Inż. Biomed. PAN, Warszawa 1994.
• [107] Uklejewski, R.; Winiecki, M., Rogala, P.; Czapski, T.: On Mechanoelectric and Electroacoustic Properties of Bone. Part 1& 2. Materials Engineering, Vol. 11. No.1, 2004, 173-182.
• [108] Urist, M.R., Lietze, A., Mizutani, H., et al.: A Bovine Low Molecular Weight Bone Morphogenic Protein (BMP) Fraction, Clin. Orthop., 1982, 162, 219.
• [109] Villar, R.: Resurfacing Arthroplasty of The Hip, J. Bone Joint Surg. Br., 2004, 86-B: 157-8.
• [110] Weish, R.P., Pilliar, R.M., Macnab, I.: Surgical Implants. The Role of Surface Porosity in Fixation to Bone and Acrylic, J. Bone Joint Surg., 53A; 963, 1971.
• [111] Wienstein, A.M., Klawitter, J.J., Cleveland, T.W., Amoss. D.C.: Electrical Stimulation of Bone Growth Into Porous Al203, J. Biomed. Mater. Res., 1976, 10, 231-247.
• [112] Williams, D.F., (Ed.): Definition in Biomaterials, Amsterdam, Oxford, New York; Tokyo, Elsevier, 1987.
• [113] Williams, D.F., Roaf, R.: Implants in Surgery, W. B. Saunders, London, 1973.
• [114] Winiecki, M.: Badanie i projektowanie cech konstrukcyjnych połączeń porowatych implantów ortopedycznych z kośćmi, /rozprawa doktorska/ - w opracowaniu.
• [115] Winiecki, M.: Zagadnienie biomechanicznej biokompatybilności kości i materiałów konstrukcyjnych implantów ortopedycznych w świetle współczesnego dwufazowego porosprężystego modelu tkanki kostnej, Maintenance and Reliability, Vol. 2(22)/ 2004, 74-79.
• [116] Wolff, J.: Das Gesetz der Transformation der Knochen, Springer-Verlag, Berlin, 1892.