Copolymers of L-lactide and trimethylene carbonate evaluation of surface properties and degradation in aqueous medium

• Autorzy: Pamuła E. , Gaugain E. , Dessart A. , Dobrzyński P.
• Języki publikacji: EN

Abstrakty

EN

Two poly(L-lactide-co-trimethylene carbanates)s having the carbonate content of 15% and 50%, respectively were prepared by ring-opening copolymerization with the use of zirconium acetylacatonate as an initiator. The copolymers were characterized by NMR,GPC, DSC and AFM. Wettability and surface energy of the copolymers were also evaluated. The copolymers were submitted to degradation in phosphate buffered saline at 37 Celcius degrees for 10 weeks. It was shown that degradation mechanism and kinetics depend on chemical structure of the copolymers.

Słowa kluczowe

EN

copolymers; L-lactide; trimethylene carbonate; degradation study; wettability; surface energy

• Wydawca: Polskie Stowarzyszenie Biomateriałów
• Czasopismo: Inżynieria Biomateriałów
• Rocznik: 2005
• Tom: R. 8, nr 47-53
• Strony: 25--27
• Opis fizyczny: Bibliogr. 6 poz., tab., rys., wykr.

Twórcy

autor

Pamuła E.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. Mickiewicza 30, 30-059 Kraków, Poland

autor

Gaugain E.

• Université du Maine, Institut Universitaire de Technologie du Mans, Avenue Olivier Messiaen, 72-085 Le Mans, France

autor

Dessart A.

• Université du Maine, Institut Universitaire de Technologie du Mans, Avenue Olivier Messiaen, 72-085 Le Mans, France

autor

Dobrzyński P.

• Centre of Polymer Chemistry, Polish Academy of Sciences, ul. Curie-Skłodowskiej 34/20, 41-819 Zabrze, Poland

Bibliografia

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• [2] Acemoglu M. "Chemistry of polymer biodegradation and implications on parental drug delivery". International Journal of Pharmaceutics 277 (2003), 133-139.
• [3] Matsumura S., Tsukada K., Toshima K., "Novel lipase-catalyzed ring-opening copolymerization of lactide and trimethylene carbonate forming poly(ester carbonate)s" International Journal of Biological Macromolecules 25 (1999) 161-167.
• [4] Södergärd A., Stolt M., "Properties of lactic acid based polymers and their corelation with composition". Progress in Polymer Science 27 (2002), 1123-1163
• [5] Fisher E.W., Sterzel D. J., Wegner G., Kolloid-Z. u. Z. Polymere 251 (1973) 980-990
• [6] Chandra R., Rustgi R., "Biodegradable Polymers" Progress in Polymer Science 23 (1998) 1273-1335.