Evaluation on safety and efficacy of ultrasound assisted thrombolysis in a sheep artificial heart pump

• Autorzy: Cui Yongchun , Zheng Xiaobing , Wang Shuo , Zhou Jianye , Yue Guangxin , Peng Peng , Li Qiuju , Li Jubo , Li Yue , Luo Jiafei , Zhang Qi , Zhang Xue , Li Yongjian , Wang Xin

Identyfikatory

DOI

10.1016/j.bbe.2024.02.003

• Języki publikacji: EN

Abstrakty

EN

Thrombosis is a major and serious complication in patients with artificial heart pump assist device (HPAD). There is an urgent need for an efficient and safe method to solve the clinical challenge. We have developed a new type of ultrasound integrated heart pump assist device (uHPAD) with a pair of ultrasonic transducer rings installed around the pump. Based on the in-vitro experiments, the sonothrombolysis protocol was determined. Then, in-vivo experiments were performed on sheep to evaluate the efficacy and safety of the novel uHPAD. It is found that the ultrasound assisted thrombolysis with the drug-loaded microbubbles can accelerate the dissolution of the thrombus in the pump, while have no significant negative effect on blood cell components, coagulation-hemolysis system, and the structure and function of main organs. The ultrasound assisted thrombolysis is demonstrated to be a promising method to solve the clinical problem of thrombosis in the HPAD.

Słowa kluczowe

EN

ultrasound assisted thrombolysis; artificial heart pump; microbubbles

PL

tromboliza wspomagana ultradźwiękami; sztuczne serce; mikropęcherzyki

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2024
• Tom: Vol. 44, no. 2
• Strony: 277--285
• Opis fizyczny: Bibliogr. 46 poz., rys., tab., wykr.

Twórcy

autor

Cui Yongchun

• Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing 102300, China

autor

Zheng Xiaobing

• Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China

autor

Wang Shuo

• Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing 102300, China

autor

Zhou Jianye

• Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing 102300, China

autor

Yue Guangxin

• Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing 102300, China

autor

Peng Peng

• Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing 102300, China

autor

Li Qiuju

• Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing 102300, China

autor

Li Jubo

• Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing 102300, China

autor

Li Yue

• Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing 102300, China

autor

Luo Jiafei

• Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing 102300, China

autor

Zhang Qi

• Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing 102300, China

autor

Zhang Xue

• Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing 102300, China

autor

Li Yongjian

• Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China

autor

Wang Xin

• Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing 102300, China

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