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In this study, polyvinyl alcohol (PVA) hydrogels designed for osteochondral regeneration were mineralized with calcium phosphate (CaP) and magnesium phosphate (MgP) by incorporation of the enzyme alkaline phosphatase (ALP) and incubation in solutions of 0.1 M calcium or magnesium glycerophosphate (CaGP, MgGP). Hydrogels incubated in water served as controls. Dry mass percentage, i.e. the percentage consisting of polymer and mineral and not water, was markedly higher for samples incubated in CaGP and MgGP and decreased in the order: CaGP>MgGP>water. CaP and MgP formation was confirmed by FTIR. SEM revealed spherical deposits characteristic for apatite in samples incubated in CaGP and plate-like crystals of the magnesium phosphate bobierrite in samples incubated in MgGP, while samples incubated in water were devoid of deposits. Rheometric testing showed that storage modulus of hydrogels incubated in CaGP and MgGP was markedly higher and decreased in the order: CaGP>MgGP>water. The results prove the principle of enzymatic mineralization of PVA with CaP and MgP to improve their suitability for bone regeneration applications.
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137--138
Opis fizyczny
Bibliogr. 5 poz., wykr.
Twórcy
autor
- Polymer Chemistry and Biomaterials (PBM) Group, Ghent University, Belgium
autor
- Division of Biomaterials and Microbiological Technologies, West Pomeranian University of Technology, Szczecin, Poland
autor
- Center for Microsystems Technology (CMST), ELIS, imec, Ghent, Belgium
autor
- Division of Biomaterials and Microbiological Technologies, West Pomeranian University of Technology, Szczecin, Poland
autor
- Polymer Chemistry and Biomaterials (PBM) Group, Ghent University, Belgium
Bibliografia
- [1] Douglas T. E. L., et al. (2012) Macromol Biosci.
- [2] Tamimi F., et al. (2012) Acta Biomater, 7, 2678-85.
- [3] El Fray M., et al. (2005) European Polymer Journal, 43, 2035-2040.
- [4] Koutsopoulus S. (2002) J Biomed Mater Res 62:600-612.
- [5] Frost R.L. et al. (2002) Mineralogical Magazine, 66, 1063-1073.
Uwagi
EN
The authors acknowledge the Research Foundation Flanders (FWO) and Ghent University for support.
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Bibliografia
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bwmeta1.element.baztech-af3bb3fa-516d-45e1-833f-7f6839db4f87