Bismuth Oxide Nanoparticles Influence on ROS generation by Targeted and Bystander Cells under Proton Beam Irradiation

• Autorzy: Rashid Raizulnasuha Ab , Sisin Noor Nabilah Talik , Zainudin Nur Hamizah Mohd , Razak Khairunisak Abdul , Geso Moshi , Akasaka Hiroaki , Sasaki Ryohei , Tominaga Takahiro , Rahman Wan Nordiana , Miura Hayato

Identyfikatory

DOI

10.2478/pjmpe-2025-0019

• Języki publikacji: EN

Abstrakty

EN

Introduction: The goals of radiotherapy to achieve a therapeutic dose for the cancer cells and lower the dose for the surrounding healthy tissues might be possible with highly localized proton beam therapy. The lethal effects can further be increased by using nanomaterials as a radiosensitizer. Material and methods: In this study, the effects of bismuth oxide nanoparticles (BiONPs) in combination with a proton beam on the targeted and bystander cells were investigated by measuring the level of reactive oxygen species (ROS) generated. Human colon carcinoma cells (HCT 116) were incubated with 0.5 mM of BiONPs and then were exposed to 150 MeV proton beams with doses of 2 to 12 Gy at the dose rate of 0.1 Gy/s in a single fraction. ROS was measured for targeted cells after irradiation, and the effect on the bystander cells was measured using irradiated cell-conditioned medium (ICCM) with and without BiONPs. Results: The results show an increase in the ROS generation for irradiated cells treated with BiONPs. Meanwhile in bystander cells, the results indicated the increment in the ROS generation for cells with BiONPs ICCM compared to those with ICCM only. Nevertheless, the population means difference in ROS levels among bystander cells at different incubation times is insignificant (p<0.05). The bystander cells treated with ICCM @ 12 Gy also did not significantly differ from unirradiated cells with BiONPs ICCM @ 0 Gy (p<0.05). Conclusion: The application of BiONPs as a radiosensitizer in combination with proton beam therapy could improve tumor control with minimal risk of normal tissue complication.

Słowa kluczowe

EN

bystander; bismuth oxide nanoparticles; reactive oxygen species; proton beams

• Wydawca: Polskie Towarzystwo Fizyki Medycznej
• Czasopismo: Polish Journal of Medical Physics and Engineering
• Rocznik: 2025
• Tom: Vol. 31, Iss. 2
• Strony: 164--170
• Opis fizyczny: Bibliogr. 51 poz., rys., tab.

Twórcy

autor

Rashid Raizulnasuha Ab

• Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, Selangor, Malaysia

autor

Sisin Noor Nabilah Talik

• Department of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia

autor

Zainudin Nur Hamizah Mohd

• School of Medical Imaging, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Terengganu, Malaysia

autor

Razak Khairunisak Abdul

• School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Pulau Pinang, Malaysia

autor

Geso Moshi

• School of Health and Biomedical Sciences, RMIT University, Victoria, Australia

autor

Akasaka Hiroaki

• Graduate School of Medicine, Kobe University, Kobe, Japan

autor

Sasaki Ryohei

• Graduate School of Medicine, Kobe University, Kobe, Japan

autor

Tominaga Takahiro

• Faculty of Health Sciences, Hiroshima International University, Hiroshima, Japan

autor

Rahman Wan Nordiana

• Nuclear Technology Research Centre, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Selangor, Malaysia
• Department of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia

autor

Miura Hayato

• Hyogo Ion Beam Medical Centre (HIBMC), Hyogo, Japan

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