Rola immunoglobuliny E w kreowaniu reakcji autoimmunologicznych

Białek, Sławomir; Białek-Gosk, Katarzyna

Artykuł - szczegóły

Tytuł artykułu

Rola immunoglobuliny E w kreowaniu reakcji autoimmunologicznych

Autorzy

Białek Sławomir , Białek-Gosk Katarzyna

Identyfikatory

Warianty tytułu

The role of immunoglobulin E in creating autoimmune reactions

Języki publikacji

Abstrakty

Przyjaciel czy wróg? To główne pytanie, na które musi odpowiedzieć układ odpornościowy u każdej osoby od poczęcia, poprzez cały okres życia. Niestety, z jakichś powodów robi to źle i generuje niewłaściwą odpowiedź immunologiczną o charakterze autoagresji bądź nadwrażliwości alergicznej. W wielu pracach nad mechanizmami przewlekłych chorób o podłożu autoimmunologicznym potwierdzono udział autoreaktywnej IgE w patomechanizmie powstawania tych chorób. Dlatego autoimmunizację za pośrednictwem autoprzeciwciał w klasie IgE zaczęto nazywać autoalergią. Jednak aby być pewnym mechanizmu autoalergicznego, konieczne jest zidentyfikowanie zarówno autoprzeciwciał IgE, jak i ich celów, jak to zostało zrobione z białkiem transbłonowym BP180 i białkiem wewnątrzkomórkowym BP230 w pęcherzycy czy IL-24 w pokrzywce przewlekłej spontanicznej. Zatem udział autoreaktywnych przeciwciał IgE w procesach autoimmunizacji wymaga jeszcze wielu badań.

Friend or foe? This is the main question that everyone’s immune system must answer from conception, throughout the whole life. Unfortunately, for some reason, it does it badly and generates wrong immune response in the form of auto-aggression or allergic hypersensitivity. The involvement of autoreactive IgE in the pathomechanism of these diseases has been confirmed in many papers on the mechanisms of chronic autoimmune disorders. Therefore, autoimmunity mediated by autoantibodies in the IgE class has begun to be called autoallergy. However, to be sure of the autoallergic mechanism, it is necessary to identify both IgE autoantibodies and their targets, as has been done with the BP180 transmembrane protein and the BP230 intracellular protein in pemphigus or IL-24 in spontaneous chronic urticaria. Therefore, the participation of autoreactive IgE antibodies in autoimmunity processes requires a lot of research.

Słowa kluczowe

autoreaktywna IgE autoimmunizacja autoantygeny astma nieatopowa pokrzywka przewlekła spontaniczna

autoreactive IgE autoimmunity autoantigens non-atopic asthma spontaneous chronic urticaria

Wydawca

ELAMED Media Group

Czasopismo

Laboratorium Medyczne

Rocznik

2020

Tom

nr 2-3

Strony

54--59

Opis fizyczny

Bibliogr. 88 poz., rys., tab.

Twórcy

autor

Białek Sławomir

autor

Białek-Gosk Katarzyna

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).

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