Synthesis, characterization, antibacterial evaluation and molecular docking studies of 2-azetidinone derivatives as novel DNA gyrase inhibitors

• Autorzy: Sulthana R. M. , Quine S. D.

Identyfikatory

DOI

10.18052/www.scipress.com/ILCPA.47.94

• Języki publikacji: EN

Abstrakty

EN

Newly designed 2-azetidinone derivatives (4a-e) were synthesized in good yields and characterised by advanced spectroscopic studies. The title compounds were evaluated for qualitative (zone of inhibition) by agar diffusion method against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Streptococcus pyogenes. Some of the analogues were found to have comparable or even more potency than the standard drugs. Docking study was performed to check interaction of synthesized compounds with the target DNA gyrase.

Słowa kluczowe

EN

hydrazone; 2-azetidinone; antibacterial activity; docking; DNA gyrase

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2015
• Tom: Vol. 47
• Strony: 94--108
• Opis fizyczny: Bibliogr. 13 poz., fot., tab., wykr., wz.

Twórcy

autor

Sulthana R. M.

• Department of Chemistry, Government Arts College, Chidambaram - 608102, India

autor

Quine S. D.

• Department of Chemistry, Government Arts College, Chidambaram - 608102, India

Bibliografia

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