Determination of sarecycline by UPLC-MS/MS and its application to pharmacokinetic study in rats

• Autorzy: Shen Yonghui , Meng Deru , Chen Feifei , Jiang Hui , Liming Hu , Zhou Yunfang , Zhang Miaomiao

Identyfikatory

DOI

10.1556/1326.2020.00796

• Języki publikacji: EN

Abstrakty

EN

Sarecycline is a narrow-spectrum antibiotic for the treatment of acne, which is a chronic inflammatory disease of the hair follicle sebaceous glands. In the study, UPLC-MS/MS was used to establish a rapid and accurate analytical method. The sarecycline was determined with poziotinib as internal standard (IS) in rat plasma. An ACQUITY UPLC HSS T3 column (2.1 × 100 mm, 1.8 μm) could performe chromatographic separation with the mobile phase (methanol: water of 0.1% formic acid) with gradient elution. The ions of target fragment were m/z 488.19→410.14 for sarecycline and m/z 492.06→354.55 for poziotinib, which could quantify the electrospray ionization of positive multiple reaction monitoring (MRM) mode. The linear calibration curve of the concentration range was 1–1,000 ng/mL for sarecycline with a lower limit of quantification (LLOQ) of 1 ng/mL. The mean recovery was between 82.46 and 95.85% for sarecycline and poziotinib in rat plasma. RSD for precision of inter-day and intra-day were between 3.24 and 13.36%, and the accuracy ranged from 105.26 to 109.75%. The developed and validated method was perfectly used in the pharmacokinetic study and bioavailability of sarecycline after intravenous and oral administration in rats.

Słowa kluczowe

EN

sarecycline; UPLC-MS/MS; pharmacokinetic study; bioavailability

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2021
• Tom: Vol. 33, no. 3
• Strony: 228--233
• Opis fizyczny: Bibliogr. 23 poz., rys., tab.

Twórcy

autor

Shen Yonghui

• Department of Orthopaedics, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, Zhejiang, 323000, China

autor

Meng Deru

• The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, Zhejiang, 323000, China

autor

Chen Feifei

• The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, Zhejiang, 323000, China

autor

Jiang Hui

• The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, Zhejiang, 323000, China

autor

Liming Hu

• Department of Pharmacy, The First People's Hospital of Wenling, Wenling, Zhejiang, 317500, China

• https://orcid.org/0000-0001-6654-5255

autor

Zhou Yunfang

• The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, Zhejiang, 323000, China

• https://orcid.org/0000-0002-4317-0865

autor

Zhang Miaomiao

• Department of Pharmacy, The First People's Hospital of Wenling, Wenling, Zhejiang, 317500, China

• https://orcid.org/0000-0002-1797-9011

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