Analyzing the presence of ten synthetic colors in selected food and drink samples using ultra highperformance liquid chromatography diode array detection analysis

• Autorzy: Deeb Ahmad A. , Abuothman Mohammad , Hailat Mohammad , Abuyaman Omar , Albizreh Ruba K.

Identyfikatory

DOI

10.1556/1326.2023.01175

• Języki publikacji: EN

Abstrakty

EN

Coloring agents in foods and drinks have been popular for centuries. This study aims to analyze the presence of ten synthetic colors (namely, (allura red (E129), amaranth (E123), sunset yellow (E110), tetrazine (E102), fast green (E143), ponceau 4R (New Coccine) (E124), erythrosin B (E127), brilliant blue FCF (E133), brilliant black (E151) and carmoisine (E122))) in food and drink samples using ultrahigh- performance liquid chromatography diode array detection (UHPLC-DAD). The present analytical method was carried out using Agilent Poroshell 120 HPH-C18 column, 3 3 100 mm, 2.7 μm, and a mobile phase consisting of 10mM Na2HPO4, pH 7, mixed with methanol as a time-increment gradient solution until the time was 20 min, then decreased with time until the time was 26 min. The pH was set by orthophosphoric acid at 7 and 5 μL injection volume, 0.50 mL flow rate, and the elution systems were monitored at 428 nm for E102, 518 nm for E124, E110, E129, E122, 530 nm for E151, E127, 622 nm for E143, and E133, respectively. The limit of detection and quantification for all colors ranged from 0.017 to 0.025 and 0.057 and 0.082 mg L_1, respectively. The correlation coefficient values ranged between 0.9991 and 1.0. The selectivity of the assay revealed no interference from other components in the analyzed samples. The percent recovery and precision (intra- and inter-day) of the spiked samples were within the acceptable limits of the ICH guidelines. Five analytical parameters were employed, and the results showed a new, novel, and robust method according to ICH guidelines for analyzing these colors. While most of the investigated food and drinks fell within the accepted range, some fell outside. The current sample preparation and analytical methods are comprehensive and universal for extracting and measuring synthetic colors in various food and drink samples.

Słowa kluczowe

EN

synthetic colors; food; drink; sample preparation; UHPLC-DAD

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2024
• Tom: Vol. 36, no. 4
• Strony: 363--370
• Opis fizyczny: Bibliogr. 33 poz., tab., wykr.

Twórcy

autor

Deeb Ahmad A.

• Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan

• https://orcid.org/0000-0001-5916-6070

autor

Abuothman Mohammad

• Automated Chemical Laboratories, Royal Scientific Society, Amman 11941, Jordan

autor

Hailat Mohammad

• Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan

autor

Abuyaman Omar

• Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa 13133, Jordan

autor

Albizreh Ruba K.

• Automated Chemical Laboratories, Royal Scientific Society, Amman 11941, Jordan

Bibliografia

• 1. Asif Ahmed, M.; Al-Khalifa, A. S.; Al-Nouri, D. M.; El-din, M. F. S. Dietary intake of artificial food color additives containing food products by school-going children. Saudi J. Biol. Sci. 2021, 28, 27–34. https://doi.org/10.1016/j.sjbs.2020.08.025.
• 2. Becker, L.; van Rompay, T. J. L.; Schifferstein, H. N. J.; Galetzka, M. Tough package, strong taste: the influence of packaging design on taste impressions and product evaluations. Food Qual. Prefer 2011, 22, 17–23. https://doi.org/10.1016/j.foodqual.2010.06.007.
• 3. Sunoqrot, S.; Al-Shalabi, E.; Al-Bakri, A. G.; Zalloum, H.; Abu-Irmaileh, B.; Ibrahim, L. H.; Zeno, H. Coffee bean polyphenols can form biocompatible template-free antioxidant nanoparticles with various sizes and distinct colors. ACS Omega 2021, 6, 2767–76. https://doi.org/10.1021/acsomega.0c05061.
• 4. Stich, E. Food color and coloring food: quality, differentiation and regulatory requirements in the European Union and the United States. Quality, differentiation and regulatory requirements in the European Union and the United States. In Handbook on Natural Pigments in Food and Beverages: Industrial Applications for Improving Food Color; Woodhead Publishing, 2016; pp 3–27, ISBN 9780081003923.
• 5. Henry, B. S. Natural food colours. In Natural Food Colorants; Springer: Boston, MA, 1996; pp 40–79.
• 6. Campos-Montiel, R. G.; Pimentel-González, D. J.; Figueira, A. C. Chemical and functional properties of food components. In Advances in Food Science and Technology;, 2013; pp 151–83, ISBN 9781118121023.
• 7. Dey, S.; Nagababu, B. H. Applications of food color and biopreservatives in the food and its effect on the human health. Food Chem. Adv. 2022, 1, 100019. https://doi.org/10.1016/J.FOCHA.2022.100019.
• 8. Ntrallou, K.; Gika, H.; Tsochatzis, E. Analytical and sample preparation techniques for the determination of food colorants in food matrices. Foods 2020, 9, 58.
• 9. Palianskikh, A. I.; Sychik, S. I.; Leschev, S. M.; Pliashak, Y. M.; Fiodarava, T. A.; Belyshava, L. L. Development and validation of the HPLC-DAD method for the quantification of 16 synthetic dyes in various foods and the use of liquid anion exchange extraction for qualitative expression determination. Food Chem. 2022, 369, 130947. https://doi.org/10.1016/j.foodchem.2021.130947.
• 10. Solfrizzo, M.; Piemontese, L.; Gambacorta, L.; Zivoli, R.; Longobardi, F. Food coloring agents and plant food supplements derived from vitis Vinifera: a new source of human exposure to Ochratoxin A. J. Agric. Food Chem. 2015, 63, 3609–14. https://doi.org/10.1021/acs.jafc.5b00326.
• 11. Maria de Souza Santos Cheibub, A.; Silva Bahiense de Lyra, E.; Jardim Alves, B.; Andrade Donagemma, R.; Duarte Pereira Netto, A. Development and validation of a multipurpose and multicomponent method for the simultaneous determination of six synthetic dyes in different foodstuffs by HPLC-UV-DAD. Food Chem. 2020, 323, 126811. https://doi.org/10.1016/j.foodchem.2020.126811.
• 12. Cifuentes, A. Recent advances in the application of capillary electromigration methods for food analysis. Electrophoresis 2006, 27, 283–303.
• 13. de Andrade, F. I.; Florindo Guedes, M. I.; Pinto Vieira, Í.G.; Pereira Mendes, F. N.; Salmito Rodrigues, P. A.; Costa Maia, C. S.; Marques Ávila, M. M.; de Matos Ribeiro, L. Determination of synthetic food dyes in commercial soft drinks by TLC and ion-pair HPLC. Food Chem. 2014, 157, 193–8. https://doi.org/10.1016/j.foodchem.2014.01.100.
• 14. Pauk, V.; Krej_cí, M.; Lemr, K. Unified chromatography – mass spectrometry as a versatile tool for determination of food dyes. Anal Chim. Acta 2021, 1157, 338401. https://doi.org/10.1016/j.aca.2021.338401.
• 15. Smirnova, S. v.; Lyskovtseva, K. A.; Pletnev, I. v. Extraction and determination of synthetic food dyes using tetraalkylammonium based liquid-liquid extraction. Microchemical J. 2021, 162, 105833. https://doi.org/10.1016/j.microc.2020.105833.
• 16. Mahale, R. S.; Shashanka, R.; Vasanth, S.; Vinaykumar, R. Voltammetric determination of various food azo dyes using different modified carbon paste electrodes. Biointerface Res. Appl. Chem. 2022, 12, 4557–66.
• 17. Mbabazi, J. Principles and methods for the risk assessment of chemicals in food. Int. J. Environ. Stud. 2011, 68, 251–2. https://doi.org/10.1080/00207233.2010.549617.
• 18. Vlase, L.; Muntean, D.; Cobzac, S. C.; Filip, L. Development and validation of an HPLC-UV method for determination of synthetic food colorants. Revue Roumaine de Chim. 2014, 59, 719–25.
• 19. Alkather, Z.; Hailat, M.; Al-Shdefat, R.; Abu Dayyih, W. Development and validation of HPLC method for five gliptins in pharmaceutical dosage forms in finished marketed products. Curr. Pharm. Anal 2020, 17, 1263–71. https://doi.org/10.2174/1573412917999201102212635.
• 20. Hailat, M.; Al-Ani, I.; Hamad, M.; Zakareia, Z.; Abu Dayyih, W. Development and validation of a method for quantification of favipiravir as COVID-19 management in spiked human plasma. Molecules 2021, 26, Page 3789 2021, 26, 3789 https://doi.org/10.3390/MOLECULES26133789.
• 21. Deeb, A. A.; Hailat, M.; Aldoqum, H. M.; Abuothman, M.; Abuyaman, O.; Abu Dayyih, W. An analytical method for determining N -nitrosodimethylamine and N –nitrosodiethylamine contamination in Irbesartan, Olmesartan and metformin by UPLCAPCI-MS/MS in tablet dosage form. J. Chromatogr. Sci. 2023. https://doi.org/10.1093/chromsci/bmad068.
• 22. Lavine, B. Chemometrics: statistics and Computer Application in Analytical Chemistry By Matthias Otto (Freiberg University of Mining and Technology). Wiley-VCH: Weinheim. 1999. $69.95. 307 Pp. ISBN 3-527-29628-X. J. Am. Chem. Soc. 2000, 122, 5903–4. https://doi.org/10.1021/ja995724t.
• 23. Araujo, P. Key Aspects of Analytical Method Validation and Linearity Evaluation. J. Chromatogr. B Analyt Technol. Biomed. Life Sci. 2009, 877, 2224–34. https://doi.org/10.1016/j.jchromb.2008.09.030.
• 24. EFSA Panel on Food Additives and Nutrient Sources added to Food Scientific Opinion on the Re-Evaluation Tartrazine (E 102). EFSA J. 2009, 7, 1331. https://doi.org/10.2903/j.efsa.2009.1331.
• 25. European Food Safety Authority Refined Exposure Assessment for Amaranth (E 123). EFSA J. 2013, 11, 3442. https://doi.org/10.2903/j.efsa.2013.3442.
• 26. EFSA Panel on Food Additives and Nutrient Sources added to Food Scientific Opinion on the Re-Evaluation of Ponceau 4R (E 124) as a Food Additive. EFSA J. 2009, 7, 1328. https://doi.org/10.2903/j.efsa.2009.1328.
• 27. EFSA Panel on Food Additives and Nutrient Sources added to Food Scientific Opinion on the Re-Evaluation of Sunset Yellow FCF (E110) as a Food Additive. EFSA J. 2009, 7, 1330. https://doi.org/10.2903/j.efsa.2009.1330.
• 28. EFSA Panel on Food Additives and Nutrient Sources added to Food Scientific Opinion on the Re-Evaluation of Allura Red AC (E 129) as a Food Additive. EFSA J. 2009, 7, 1327. https://doi.org/10.2903/j.efsa.2009.1327.
• 29. EFSA Panel on Food Additives and Nutrient Sources added to Food Scientific Opinion on the Re-Evaluation of Azorubine/Carmoisine (E 122) as a Food Additive. EFSA J. 2009, 7, 1332. https://doi.org/10.2903/j.efsa.2009.1332.
• 30. European Food Safety Authority Refined Exposure Assessment for Brilliant Black BN (E 151). EFSA J. 2015, 13, 3960. https://doi.org/10.2903/j.efsa.2015.3960.
• 31. EFSA Panel on Food Additives and Nutrient Sources added to Food Scientific Opinion on the Re-Evaluation of Erythrosine (E 127) as a Food Additive. EFSA J. 2011, 9, 1854. https://doi.org/10.2903/j.efsa.2011.1854.
• 32. World health Organization (WHO) Fast Green , FCF . Stain. Available online: https://apps.who.int/food-additives-contaminantsjecfa-database/Home/Chemical/1356 (accessed on October 5, 2022).
• 33. Kumar, N.; Raghavendra, M.; Tokas, J.; Singal, H. R. Flavor Addition in Dairy Products: Health Benefits and Risks. In Nutrients in Dairy and Their Implications for Health and Disease; Academic Press, 2017; pp 123–35, ISBN 9780128097632.