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Tytuł artykułu

Flavonoids and their properties to form chelate complexes

Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The medical properties of naturally occurring compounds such as flavonoids have been well known for many years. However, the discovery that complexes of flavonoids with metal ions are more effective than free flavonoids changed the course of chemistry research. Flavonoids can be effective drugs because of their potent chelating or neuroprotective, radical scavenging and anti-inflammatory properties. Our paper is a literature review about flavonoids and their complexes which are generally used in medicine and pharmacy.
Rocznik
Strony
35--41
Opis fizyczny
Bibliogr. 27 poz.
Twórcy
autor
  • Institute of General Food Chemistry, Lodz University of Technology, 90-924 Lodz, Poland
autor
  • Institute of General Food Chemistry, Lodz University of Technology, 90-924 Lodz, Poland
Bibliografia
  • 1. Leopoldini M, Russo N, Chiodo S, Toscano M. Iron chelation by the powerful antioxidant flavonoid quercetin. J Agric Food Chem 2006, 54:6343-6351.
  • 2. Cao G, Sofic E, Prior R.L. Antioxidant and pro-oxidant behavior of flavonoids; structure-activity relationships. Free Radical Biol Med 1997, 22:749-760.
  • 3. Lu J, Papp LV, Fang J, Rodriguez-Nieto S, Zhivotovsky B, Holmgren A. Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer Res 2006, 66, 4410-4418.
  • 4. Bukhari SB, Memon S, Tahir MM, Bhanger MI. Synthesis, characterization and antioxidant activity copper-quercetin complex. Spectrochim Acta A Mol Biomol Spectrosc 2009, 71, 1901-1906.
  • 5. Barve V, Ahmed F, Adsule S, Banerjee S, Kulkarni S, Katiyar P, Anson CE, Powell AK, Padhye S, Sarkar FH. Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J Med Chem 2006, 49:3800-3808.
  • 6. Leopoldini M, Marino T, Russo N, Toscano M. Antioxidant properties of phenolic componds: H-atom versus electron transfer mechanism. J Phys Chem A 2004, 108:4916-4923.
  • 7. Kim YJ, Bae YC, Suh KT, Jung JS. Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells Biochem Pharmacol 2006, 72:1268-1276.
  • 8. Morales AI, Vicente-Sánchez C, Santiago Sandoval JM, Egido J, Mayoral P, Arévalo MA, Fernández-Tagarro M, López-Novoa JM, Pérez-Barriocanal F. Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties. Food Chem Toxicol 2006, 44:2092-2100.
  • 9. Luangaram S, Kukongviriyapan U, Pakdeechote P, Kukongviriyapan V, Pannangpetch P. Protective effects of quercetin against phenylhydrazine-induced vascular dysfunction and oxidative stress in rats. Food Chem Toxicol 2007, 45:448-456.
  • 10. Torreggiani A, Tamba M, Trinchero A, Bonora S. Copper(II)-Quercetin complexes in aqueous solutions: Spectroscopic and kinetic properties. J Mol Struct 2005, 759:744-751.
  • 11. Mladěnka P., Zatloukalová L., Filipský T., Hrdina R. Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Rad Biol Med 2010, 49: 963-975.
  • 12. Jurd L, Geissman TA. The chemistry of flavonoid compounds. J Org Chem 1956, 21:1395-1401.
  • 13. Kostyuk VA, Potapovich AI, Vladykovskaya EN, Korkina LG, Afanas'ev IB. Influence of metal ions on flavonoid protection against asbestos-induced cell injury. Arch Biochem Biophy 2001, 385, 129-137.
  • 14. Moridani MY, Pourahmad J, Bui H, Siraki A, O'Brien PJ. Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers. Free Rad Biol Med, 2003,34, 243-253.
  • 15. De Souza RF, Sussuchi EM, De Giovani WF. Synthesis, electrochemical, spectral, and antioxidant properties of complexes of flavonoids with metal ions. Synth React Inorg Met-Org Chem 2004, 33:1125-1144.
  • 16. Bravo A, Anacona JR. Metal complexes of the flavonoid quercetin: antibacterial properties. Transit Met Chem 2001, 26, 20-23.
  • 17. Bukhari SB, Memon MM, Tahir MI, Bhanger I. Synthesis, characterization and antioxidant activity copper–quercetin complex. Spectrochim Acta Part A 2009, 71:1901-1906.
  • 18. Zhou J, Wang L, Wang J, Tang N. Synthesis, characterization, antioxidative and antitumor activities of solid quercetin rare earth(III) complexes. J Inorg Biochem 2001, 83, 41-48.
  • 19. Brown JE, Khodor H, Hider RC, Rice-Evans CA. Structural dependence of flavonoid interactions with Cu2+ ions: Implications for their antioxidant properties. Biochem J 1998, 330: 1173-1180
  • 20. Anafas'ev IB, Ostrakhovitch EA, Mikhal V, Ibragimova L, Korkina GA. Enhancement of antioxidant and anti-inflammatory activities of bioflavonoid rutin by complexation with transition metals. Biochem Pharmacol 2001, 61, 677-684.
  • 21. Mira L, Fernandez MT, Santos M, Rocha R, Florencio MH, Jennings KR. Interactions of flavonoids with iron and copper ions: A mechanism for their antioxidant activity. Free Rad Res 2002, 36, 1199-208.
  • 22. Tang H, Wang X, Yang S, Wang L. Synthesis, characterization, and biological activities of Pt(II) and Pd(II) complexes with 2',3,4',5,7-pentahydroxyflavone. Rare Metals 2004, 23, 38-42.
  • 23. Chen X, Tang LJ, Sun YN., Qiu PH, Liang GJ. Syntheses, characterization and antitumor activities of transition metal complexes with isoflavones J Inorg Biochem 2010, 104:379-384.
  • 24. Dowling S, Regan F, Hughes H. The characterisation of structural and antioxidant properties of isoflavone metal chelates J Inorg Biochem 2010, 104:1091-1098.
  • 25. Yuldashev R Kh, Makhkamov Kh. M, Sharipov Kh. T., Aliev Kh U. Synthesis and study by IR and UV methods of spectral analysis of a complex of Mo(VI) with quercetin Chem Nat Comp 1999, 35, 420-421.
  • 26. Hider RC, Hall AD, Clinically Useful Chelators of Tripositive Elements. Prog Med Chem 1991, 28, 41-173.
  • 27. Dobbin PC, Hider R Venkatramani L, Siripitayananon J, Vanderhelm D. Synthesis and structure of the N-alkyl-2,6-dimethyl-4-oxopyridine-3-carboxylic acids. J Heterocycl Chem 1993, 30, 723-737.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-a9ebcc69-6264-4ea7-acdb-b0fb69b854ac
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