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Tytuł artykułu

Reversed-phase TLC study of the lipophilicity of some 3-hydroxy-1,2-benzisoxazoles substituted in the benzene ring

Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The relative lipophilicity, R M0 , and specific hydrophobic surface area of eleven 3-hydroxy-1,2-benzoisoxazoles substituted in the benzene ring (two isomeric fluoro, three isomeric chloro, three isomeric bromo and dibromo derivatives, and a nitro derivative) have been studied by reversed-phase thin layer chromatography (RP-TLC) on silica gel RP-C18 plates with methanol-water mixtures as mobile phases. Linear correlation between the volume fraction of methanol and R M values over a limited range was established with high correlation coefficients ( r > 0.99). Lipophilicity R M0 was compared with computed partition coefficients IAlogP, A logP s , clogP, milogP, logP KOWIN , and xlogP. The best correlation ( r > 0.9) was found between R M0 and logP KOWIN and xlogP values. Principal-components analysis (PCA) was also used to compare R M0 values with computed partition coefficients. The chromatographic behaviour of 3-hydroxy-1,2-benzisoxazoles was compared with that of their bioisosteric analogues 1,2-benzisot-iazolonoles. Experimental R M0 values for both groups of compounds were in accor-dance with the equation R M0 aR M0 +b(r> 0.9).
Rocznik
Strony
251--258
Opis fizyczny
Bibliogr. 27 poz., rys., tab.
Twórcy
autor
  • Medical University of Lublin Department of Medicinal Chemistry, Pharmaceutical Faculty Jaczewskiego 4 20-090 Lublin Poland
  • Medical University of Lublin Department of Medicinal Chemistry, Pharmaceutical Faculty Jaczewskiego 4 20-090 Lublin Poland
autor
  • Medical University of Lublin Department of Medicinal Chemistry, Pharmaceutical Faculty Jaczewskiego 4 20-090 Lublin Poland
autor
  • Medical University of Lublin Department of Medicinal Chemistry, Pharmaceutical Faculty Jaczewskiego 4 20-090 Lublin Poland
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-a90bc98e-478b-43c1-b2ec-da16ea12d87e
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