Epigenetics is promising direction in modern science

• Autorzy: Fartushok Tetiana , Kovalyshyn Orysia , Fedevych Yuri , Tanchyn Igor , Zhykovskiy Volodymyr

Identyfikatory

DOI

10.2478/cdem-2021-0010

• Języki publikacji: EN

Abstrakty

EN

Epigenetics studies the inherited changes in a phenotype or in expression of genes caused by other mechanisms, without changing the nucleotide sequence of DNA. The most distinguished epigenetic tools are: modifications of histones, enzymatic DNA methylation, and gene silencing mediated by small RNAs (miRNA, siRNA). The resulting m5C residues in DNA substantially affect the cooperation of proteins with DNA. It is organized by hormones and aging-related alterations, one of the mechanisms controlling sex and cellular differentiation. DNA methylation regulates all genetic functions: repair, recombination, DNA replication, as well as transcription. Distortions in DNA methylation and other epigenetic signals lead to diabetes, premature aging, mental dysfunctions, and cancer.

Słowa kluczowe

EN

epigenetics; 5-methylcytosine; DNA methylation; histone

PL

epigenetyka; 5-metylocytozyna; metylacja DNA; histon

• Wydawca: Towarzystwo Chemii i Inżynierii Ekologicznej
• Czasopismo: Chemistry-Didactics-Ecology-Metrology
• Rocznik: 2021
• Tom: R. 26, NR 1-2
• Strony: 123--135
• Opis fizyczny: Bibliogr. 59 poz., tab., il.

Twórcy

autor

Fartushok Tetiana

• Danylo Halytsky Lviv National Medical University, Pekarska, 69, 79010, Ukraine, phone [phone]

• https://orcid.org/0000-0001-6571-0108

autor

Kovalyshyn Orysia

• Danylo Halytsky Lviv National Medical University, Pekarska, 69, 79010, Ukraine, phone [phone]

• https://orcid.org/0000-0002-9710-0694

autor

Fedevych Yuri

• Danylo Halytsky Lviv National Medical University, Pekarska, 69, 79010, Ukraine, phone [phone]

• https://orcid.org/0000-0002-2536-8376

autor

Tanchyn Igor

• Danylo Halytsky Lviv National Medical University, Pekarska, 69, 79010, Ukraine, phone [phone]

• https://orcid.org/0000-0002-0863-4732

autor

Zhykovskiy Volodymyr

• Danylo Halytsky Lviv National Medical University, Pekarska, 69, 79010, Ukraine, phone [phone]

• https://orcid.org/0000-0002-0594-5316

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