Unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine

• Autorzy: Alavi Abass , Werner Thomas J. , Stępień Ewa Ł. , Moskal Paweł

Identyfikatory

DOI

10.1515/bams-2021-0186

• Języki publikacji: EN

Abstrakty

EN

Positron emission tomography (PET) imaging is the most quantitative modality for assessing disease activity at the molecular and cellular levels, and therefore, it allows monitoring its course and determining the efficacy of various therapeutic interventions. In this scientific communication, we describe the unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine. We emphasize the critical importance of the development and synthesis of novel radiotracers (starting from the enormous impact of F-Fluorodeouxyglucose (FDG) introduced by investigators at the University of Pennsylvania (PENN)) and PET instrumentation. These innovations have led to the total-body PET systems enabling dynamic and parametric molecular imaging of all organs in the body simultaneously. We also present our perspectives for future development of molecular imaging by multiphoton PET systems that will enable users to extract substantial information (owing to the evolving role of positronium imaging) about the related molecular and biological bases of various disorders, which are unachievable by the current PET imaging techniques.

Słowa kluczowe

EN

FDG; molecular imaging; PET; positronium imaging; theranostics; total body imaging

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2021
• Tom: Vol. 17, no. 4
• Strony: 203--212
• Opis fizyczny: Bibliogr. 72 poz., rys.

Twórcy

autor

Alavi Abass

• Department of Radiology, Hospital of the University of Pennsylvania, 3400, Spruce St, Philadelphia, PA 19104, USA, Phone: [phone], Fax: [phone]

autor

Werner Thomas J.

• Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

autor

Stępień Ewa Ł.

• Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Theranostics Center, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0003-3589-1715

autor

Moskal Paweł

• Faculty of Physics, Astronomy, and Applied Computer Science, Jagiellonian University Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Theranostics Center, Jagiellonian University, Kraków, Poland

• https://orcid.org/0000-0002-4229-3548

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).