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Convenient synthesis of the 2,5-di-substituted 1,3,4-oxadiazole derivatives under microwave

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
We have reported some novel 1,3,4-oxadiazole synthesized by conventional method as well as microwave assisted method. The reaction of different substituted cinnamic acid 2a-o with 2-(4-chlorophenyl) acetohydrazide by using phosphoric anhydride as catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole 6a-o. The structures of all synthesized compounds are well characterized by Mass, FT-IR, 1H NMR, 13C NMR and elemental analysis. After obtaining experimental data regarding the yield and the time taken for the synthesis by both the methods, conventional and microwave assisted method, it was proved that the microwave assisted method is convenient for synthesis of this type of 2,5-di-substituted 1,3,4-oxadiazole 6a-o.
Rocznik
Strony
159--166
Opis fizyczny
Bibliogr. 14 poz., wykr., wz.
Twórcy
autor
  • Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujrat, India
autor
  • Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujrat, India
Bibliografia
  • [1] Potts, K. In Compr. Heterocyclic Chem.; Katritzky, A.R., Rees, Ch., Eds.; Pergamon Press: NY; 6 (1984) 427.
  • [2] Kulkarni Y. D., Rowhani A., J. Indian Chem. Soc. 66 (1989) 492.
  • [3] Mohamed Ashraf Ali, Mohammad Shaharyar, Bioorganic & Medicinal Chemistry Letters 17 (2007) 3314-3316.
  • [4] Neelam Jain, D. P. Pathak, Pradeep Mishra, Sandeep Jain, Der Pharmacia Lettre, 5 (2013) 415-418.
  • [5] S. L. Gaonkar, K. M. L. Rai, B. Prabhuswamy, Eur. J. Med. Chem. 41 (2006) 841-846.
  • [6] Zampieri D., et al., Bioorg. Med. Chem. 17 (2009) 4693-4707.
  • [7] B. Chandrakantha, Prakash Shetty, Vijesh Nambiyar, Nishitha Isloor, Arun M. Isloor, European Journal of Medicinal Chemistry 45 (2010) 1206-1210.
  • [8] Samir Bondock, Shymaa Adel, Hassan A. Etman, Farid A. Badria; European Journal of Medicinal Chemistry 48 (2012) 192-199.
  • [9] Rajesh A. Rane, Pavankumar Bangalore, Sheetal D. Borhade, Preeti K. Khandare, European Journal of Medicinal Chemistry 70 (2013) 49-58.
  • [10] Jansen M., et al., H. J. Med. Chem. 51 (2008) 4430-4448.
  • [11] P. C. Unangast, G. P. Shrum, D. T. Conner, C. D. Dyer, D. J. Schrier, J. Med. Chem. 35 (1992) 3691–3698.
  • [12] V. Ravichandran, S. Shalini, K. Sundram, A. Dhanaraj Sokkalingam, European Journal of Medicinal Chemistry 45 (2010) 2791-2797.
  • [13] Omar F. A., Mahfouz N. M., Rahman, M. A., Eur. J. Med. Chem.Chim. Ther. 31 (1996) 819.
  • [14] Dipti L. Namera, Jaynt B. Rathod, Rupali H. Maheta, Umed C. Bhoya, International Letters of Chemistry, Physics and Astronomy 10 (2014) 46-54.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-a813b3eb-0055-46a4-9e37-c284ce133bb0
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