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There has been a lively interest on macrocyclic polyamine alkaloids due to their remarkable pharmacological activities such as anti-tumor, anti-inflammatory, anti-Alzheimer's disease and anti-parasitic. Tripterygium wilfordii is a widely used traditional Chinese medicine, which is abundant in alkaloids including macrocyclic polyamine alkaloids. However, there are rarely studies on macrocyclic spermidine alkaloids of T. wilfordii so far. In this article, we use three known macrocyclic spermidine alkaloids celafurine, celabenzine and celacinnine, and successfully develop a simple and sensitive HPLC method for simultaneous quantification of macrocyclic spermidine alkaloids in root, stem and leaf of T. wilfordii.
Czasopismo
Rocznik
Tom
Strony
139--143
Opis fizyczny
Bibliogr. 10 poz., rys., tab., wykr.
Twórcy
autor
- Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, 330004, China
- College of Animal Pharmaceutical Sciences, Jiangsu Agri-animal Husbandry Vocational College, Taizhou, 225300, China
autor
- Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, 330004, China
autor
- Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, 330004, China
autor
- Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, 330004, China
Bibliografia
- 1. da Silva, G.; Martinho, A.; Soengas, R. G.; Duarte, A. P.; Serrano, R.; Gomes, E. T.; Silva, O. A new spermidine macrocyclic alkaloid isolated from Gymnosporia arenicola leaf. Fitoterapia. 2015, 106, 7–11.
- 2. Liu, J.; Wu, Q.; Shu, J.; Zhang, R.; Liu, L. A Novel spermidine macrocyclic alkaloid from the roots of Tripterygium wilfordii. Chem. Nat. Compdþ. 2020, 56, 496–9.
- 3. Wang, J.-X.; Zhao, Y. P.; Du, N.-N.; Han, Y.; Li, H.; Wang, R.; Xu, Y.; Liu, Y.-F.; Liang, X.-M. Scocycamides, a pair of macrocyclic dicaffeoylspermidines with butyrylcholinesterase inhibition and antioxidation activity from the roots of scopolia tangutica. Org. Lett. 2020, 22, 8240–4.
- 4. Hamilton, C. J.; Saravanamuthu, A.; Fairlamb, A. H.; Eggleston, I. M. Benzofuranyl 3,5-bis-Polyamine derivatives as time-Dependent inhibitors of trypanothione reductase. Bioorg. Med. Chem. 2003, 11, 3683–93.
- 5. Hamilton, C. J.; Saravanamuthu, A.; Poupat, C.; Fairlamb, A. H.; Eggleston, I. M. Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products. Bioorg. Med. Chem. 2006, 14, 2266–78.
- 6. Liu, L.; Yan, J.; Shu, J. C.; Liu, J. Q. Advance on alkaloids from Tripterygium wilfordii and their bioactivities. Nat. Prod. Res. Dev. 2019, 31, 2170–81.
- 7. Liu, L.; Jiang, H. X.; Sun, Q.; Chen, S.; Liu, J. Q. Study on the mass spectrometry fragmentation regularity and rapid identification of macrocyclic polyamine alkaloids from Tripterygium wilfordii. Chin Pharm. 2021, 32, 1944–8.
- 8. Drandarov, K.; Hesse, M. Lithium and proton templated ω-polyazamacrolactamization, new general routes to macrocyclic polyamines. Tetrahedron Lett. 2002, 43, 7213–6.
- 9. Tawil, B. F.; Guggisberg, A.; Hesse, M. Synthesis of the spermidinealkaloid (±)-N-acetyl-N(1)-deoxymayfoline. Tetrahedron. 1992, 48, 3775–80.
- 10. Jiang, J.; Liu, Y. T. Fingerprints of wild or cultivated Tripterygium wilfordii in different growing years and gathering periods. Chin. Tradit. Patent. Med. 2019, 41, 2420–4.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-a7d8f4e8-497c-4e86-9276-4a9867bfaec9